Endocrine Abstracts

The purpose of the study: Is to study features of cardiovascular complications in patients with Cushing syndrome in the Republic of Uzbekistan (RUz).

Material and research methods: In the period of 2002 to 2021, 317 patients were installed with the following clinical forms of Cushing syndrome (CS): 1) ACTH-dependent CS (ACTH-DCS) - 258 (81.3%) patients, of which women -174 (54.8%), men - 84 (26.4%), 2) ACTH independent CS (ACTH-iCS) -51 patients (16.08%) of women - 41 (12.9%), men - 10 (3.15%). 3) Ectopic CS (ACTH-ECS) -8 patients (2.5%) of women-5 (1.5%), men-3 (0.94%). The average age during the manifestation of men amounted to 26.38 ± 3.4 years, women - 27.58 ± 3.4 years. The illness of the disease ranged from 4 months to 25 years. 10 patients amounted to a control group. The study used clinical and biochemical, hormonal studies (serum, urine), functional tests, as well as instrumental (neurophthalmological, radiological - MRI pituitary gland, MSCT of adrenal glands, X-ray absorption densitometry and statistical techniques.

Results: The most frequent complications of the CS were cardiovascular complications (CVC), which developed in 113 (48.9%) patients with a predominance of female 74 (61.3%)\. Among them, malignant arterial hypertension, acute vascular disasters in the form of myocardial infarction took place more often. In the 1st group of patients with ACTH- DCS total in men, the CVC frequency was 45 (53.5%), and among women - 80 (45.9%), only 125 cases out of 258 (48.4%). In the 2 group of patients with ACTH-iCS among men the CVC frequency was 2 (20.0%), and among women - 13 (31.7%), only 15 cases out of 51 (29.4%). And, finally, in a 3group of patients with ACTH- ECS in men, the CVC frequency was 1 (33.3%), and among women - 1 (31.7%), only 2 cases of 8 (20%).

Conclusions: Of 317 patients with CS in 142 (44.8%) cardio-vascular complications were recorded and more often in the 1 st group of patients.