Endocrine Abstracts

Objective: To create a national register of prolactin-secreting pituitary adenomas to assess the prevalence of various forms and the effectiveness of therapy.

Material and research methods: National register of patients with pituitary prolactinomas in the Republic of Uzbekistan, includes 172 cases with pituitary prolactinomas, of which 61% (105 women) and 37.2% (64 men), aged 17-74 years, mean age 38.5 ± 12.6 years and 3 (1.7%) children and adolescents. All 172 patients underwent studies of somatic, endocrine, gynecological status, the levels of prolactin, LH, FSH, TSH, free T4, progesterone, estradiol, testosterone, IHLA method, MRI of the chiasmatic - selar region were studied.

Results: Prolactinomas were more common in women (62.7%) than in men (37.2%), with a predominance of their frequency in women aged 21-30 years (66.7%), in men aged 41-50 years (59, 3%). Depending on the size, the patients were distributed as follows: microadenomas 98 (5.7%), macroadenomas -53 (30.8%), giant adenomas with aggressive growth 21 (12.2%). Prolactin levels varied from 7.8 to 530 ng/ml on average in men 94 ± 3.7 in women - 162 ± 9.4 ng/ml. According to the applied methods of treatment: 128 patients (74.4%) are on drug therapy with modern drugs of dopamine agonists, transsphenoidal adenomectomy in 44 patients (25.6%), including 21 with giant (12.2%), 12 with macroadenoma (7%)) and 10 with resistant prolactinomas (5.8%). Treatment outcomes were euprolactinemia in 142 (82.5%), persistent hyperprolactinemia against the background of SPTS in 31 (18%), panhypopituitarism in 28 (16.3%), remission was not achieved in 8 (4.6%)), fertility disorders in 57 (33.1%), including 8 men and 49 women, continue to occur.

Conclusion: Pituitary prolactinoma affects young women and men, predooming them to long-term medication and are a serious cause of infertility in both sexes.