Endocrine Abstracts

Introduction/Objective: Chronic exposure to hypersomatotropism exposes to multiple co-morbidities, rarely reversible, which can worsen both functional and vital prognosis and impair quality of life. The aim of our work is to list the different complications of acromegaly at the time of diagnosis.

Patients and methods: Descriptive cross-sectional study concerning 81 patients with somatotropic adenomas followed in the Endocrinology department of the Oran University Hospital.

Results: Sex ratio M/F at 1.4, pituitary macroadenomas are involved in 81% of cases, the mean age at diagnosis at 40.2 ± 15.5 years, the mean consultation time at 23.8 ± 31.3 months, the mean BMI at 26.4 ± 4.9 kg/m². At diagnosis, we identified hypertension in 41% of cases with a mean duration of 4.5 ± 5.9 years, congestive valvular heart disease with or without arrhythmia in 31% of cases, sleep apnnea syndrome (SAS) in 50% of cases explored (n= 20), diabetes mellitus in 35% of cases with a mean duration of 5.2 ± 6.5 years, intolerance to carbohydrates in 15.3% of cases with a mean duration of 2.0 ± 3.1 years, dyslipidemia in 28%, axial arthropathy in 39% of cases including 3 Erdheim spondylosis and carpal tunnel syndrome in 40% of cases.

Discussion: Our results are similar to those in the literature which vary from 18-60% for hypertension, from 19 to 56% for diabetes mellitus and carbohydrate intolerance, from 33 to 47% for dyslipidemia and from 20 to 80% for SAS; They reflect the need for early diagnosis of acromegaly and for hormonal control to improve prognosis.