Endocrine Abstracts

The purpose of the study is to study the correlation bond indicators of ultrasonic doppler and neuromarker BDNF in blood in patients with diabetes mellitus type 2 (DM 2) with diabetic neuropathy at the later complications stage

Material and research methods: A study was conducted 215 patients with DM 2, of which 160 persons suffering from diabetic neuropathy (DNP) in the late complications stage. The following groups of patients were formed: 1 gr. - patients with DM2 type without DNP - 55 patients, 2 gr. - Patients of the DNP in the stage of late complications - 160 patients. In the study, the patients were subjected to clinical and biochemical methods of the study (Glycemia, HBA1C, Alt, Ast, Bilirubin, Urea, Creatine, BDNF, etc.), as well as instrumental examination methods - ECG, Electroneuromyography, Doppler Vessels of the lower extremities, and etc

Research results: Revealed significant correlations of BDNF levels and a number of laboratory and instrumental indicators. A correlation bond with a level of HBA1C and doppler indicators in both groups of patients was detected. In this case, the connection with the glycemia on an empty stomach was unreliable. All the above data indicate the need for timely adequate conservative therapy of chronic wound defects of the lower limbs in patients with DM 2, developing the prevention measures for their recurrence and organizing long-term observation of patients with high risk of development of this complication of diabetes.

Conclusions: The correlation relationship with a level of glycated hemoglobin, blood flow rate in the femoral artery, in the leg, the pulsation index in the tibial artery and the index of resistance in the femoral artery