ECE2022 Eposter Presentations Adrenal and Cardiovascular Endocrinology (131 abstracts)
Prevalence and clinical manifestations of neurogenic bladder dysfunction in type 2 diabetes: a population-based survey
Faten Haj Kacem Akid 1 , Abdel Mouhaymen Missaoui 1 , Mariem Belhoul 2 , Wafa Belabed 1 , Cyrine Chahaider 1 , Dhoha Ben Salah 1 , Mnif Fatma 1 , Nadia Charfi 1 , Mouna Mnif 1 , Nabila Rekik Majdoub 1 , Mouna Elleuch 1 & Mohamed Abid 1
1Hedi Chaker University Hospital, Endocrinology Departement, Sfax, Tunisia; 2Faculty of Medicine of Sfax, Departement of Family Medicine, Sfax, Tunisia.
Background and aims: Lower urinary tract (LUT) symptoms are one of the most common complications related to autonomous diabetic neuropathy. It is responsible for several dysfunctions due to distended bladder with a high risk of contracting retention. The current survey aims to assess the clinical manifestations of neurogenic bladder dysfunction (NBD) and determine its prevalence in patients with type 2 diabetes (T2DM).
Patients and method: We conducted a cross-sectional descriptive study that included 200 patients with T2DM consulting at the Endocrinology Department of Hedi Chaker University Hospital, Sfax, Tunisia, from April 2019 to December 2019. We administrated the Urinary Symptom Profile (USP) questionnaire to all patients to assess clinical manifestations of NBD.
Results: The mean age was 59.3±10.6 years, with a female predominance (55.5%). Dyslipidemia (57%) and hypertension (49.7%) were the most common comorbidities. The duration of the evolution of diabetes was 11.0±7.9 years. Oral antidiabetic agents (OAD) and insulin therapy were prescribed in 40% and 13.6%, respectively. Most of the patients were receiving a mixed insulin-OAD treatment (44.2%). A glycemic imbalance was noted in 79.7%. Stress urinary incontinence prevailed in 22.5%. the discomfort linked to this dysfunction was mild or moderate in 53.3% and 42.2%, respectively. An overactive bladder was recorded in 70.5% and caused severe or extreme discomfort for 24.1% and 16.3% of patients, respectively. Near one-half of investigated patients (51.5%) reported dysuria. The latter disorder was responsible for serious distress for 26.2% of patients. In total, the prevalence of LUT dysfunction was as high as 79.5% of patients with T2DM.
Conclusion: NBD is a cluster of lower urinary tract disorders such as stress urinary incontinence, dysuria, and overactive bladder. NBD is considered a chronic diabetic complication [1]. The prevalence of NBD varies from 25% to 87% in different studies. Urodynamic studies remain the gold standard diagnostic tool. However, the USP questionnaire represents a simple and very sensitive questionnaire for screening of NBD in patients with diabetes in clinical practice [2]. Due to its frequency, NBD should be screened for in patients with diabetes suffering from LUT dysfunctions.
References: 1. Golbidi, Saeid, and Ismail Laher. “Bladder dysfunction in diabetes mellitus.” Frontiers in pharmacology 1 (2010): 136.
2. Bansal, Rahul, et al. “Urodynamic profile of diabetic patients with lower urinary tract symptoms: association of diabetic cystopathy with autonomic and peripheral neuropathy.” Urology 77.3 (2011): 699–705.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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