ECE2022 Eposter Presentations Late Breaking (59 abstracts)
Endocrinological and inflammatory markers in individuals with spinal cord injury: A systematic review and meta-analysis
Gabriela Böhl 1 , Peter Francis Raguindin 1,2,3 , Ezra Valido 1 , 4 , Alessandro Bertolo 1 , 5 , Oche Adam Itodo 1,2,3 , Beatrice Minder 6 , Patricia Lampart 7 , Anke Scheel-Sailer 7 , Alexander Leichtle 8 , Marija Glisic 1 , 2 & Jivko Stoyanov 1,2
1Schweizer Paraplegiker-Forschung, SCI Population Biobanking and Translational Medicine Group, Nottwil, Switzerland; 2University of Bern, Institute of Social and Preventive Medicine, Bern, Switzerland; 3University of Bern, Graduate School for Health Sciences, Bern, Switzerland; 4University of Lucerne, Department of Health Sciences and Medicine, Luzern, Switzerland; 5Inselspital, Department of Orthopedic Surgery, Bern, Switzerland; 6University of Bern, Public Health & Primary Care Library, Bern, Switzerland; 7Schweizer Paraplegiker-Zentrum, Nottwil, Switzerland; 8Inselspital, University Institute of Clinical Chemistry, Bern, Switzerland
Background: Spinal cord injury (SCI) can lead to dramatic physiological changes which can be a factor in developing secondary health conditions and might be reflected in biomarker changes in this elevated risk group. We focused specifically on the endocrine and inflammation profile differences between SCI and able-bodied individuals (ABI).
Objectives: To determine the differences in inflammatory and endocrine markers profiles between individuals with SCI and ABI.
Methods: We systematically searched 4 electronic databases for relevant studies. Data was extracted and assessed by two independent reviewers. Weighted mean difference between SCI and ABI was calculated using random-effects models. Heterogeneity was computed using I2 statistic and chi-squared test. Study quality was evaluated through the Newcastle-Ottawa Scale.
Results: The search strategy yielded a total of 2,603 records after duplicates were removed. Titles and abstracts of records were screened, from which 256 articles were selected for full-text assessment. Sixty-two studies were included in the meta-analysis. Most of the studies were conducted only among male SCI individuals (68%), had a sample size of or fewer than 100 participants (74%), and were conducted in North America (40%). The mean age of the study population ranged from 16 to 64 years and the mean injury duration ranged from <1 to 29 years, with the majority of studies containing both individuals with tetraplegia and paraplegia (77%). One-third of the studies (31%) included individuals with complete injury, while 40% of the studies had both complete and incomplete injury. Most of the studies were classified as being of moderate quality (71%). SCI individuals had higher levels of pro-inflammatory C-reactive protein and IL-6 than ABI. Creatinine and Vitamin D levels were lower in SCI than ABI. Total testosterone levels and IGF-1 were also found to be lower, while cortisol and leptin levels were higher in SCI when compared to ABI. However, no significant differences were found regarding glucose and insulin. Accordingly, meta-regression, subgroup analysis, and leave-one-out analysis, were performed, however they were able to only partially explain the high levels of heterogeneity.
Conclusion: Individuals with SCI show higher levels of inflammatory markers and present significant endocrinological changes when compared to ABI. Moreover, higher incidence of obesity, diabetes, osteoporosis and hypogonadism in SCI individuals, together with decreased creatinine levels reflect some of the readily measurable aspects of the phenotype changes in the SCI group. These findings need to be considered in anticipating related medical complications and personalizing SCI medical care.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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