ECE2022 Eposter Presentations Late Breaking (59 abstracts)
Sex difference in the association of cortisol excess severity with osteoporosis and osteopenia prevalence in cortisol-producing adrenal adenoma
Shoichiro Izawa 1 , Kazuhisa Matsumoto 1 , Kazuhiko Matsuzawa 1 , Takuyuki Katabami 2 , Takanobu Yoshimoto 3 , Michio Otsuki 4 , Masakatsu Sone 5 , Yoshiyu Takeda 6 , Shintaro Okamura 7 , Takamasa Ichijo 8 , Mika Tsuiki 9 , Tomoko Suzuki 10 , Mitsuhide Naruse 11 & Akiyo Tanabe 12
1Tottori University Faculty of Medicine, Division of Endocrinology and Metabolism, Yonago, Japan; 2St. Marianna University School of Medicine Yokohama City Seibu Hospital, Division of Metabolism and Endocrinology, Department of Internal Medicine, Yokohama, Japan; 3Tokyo Medical and Dental University, Department of Molecular Endocrinology and Metabolism, Tokyo, Japan; 4Tokyo Women’s Medical University, Department of Endocrinology, Tokyo, Japan; 5St. Marianna University School of Medicine, Division of Metabolism and Endocrinology, Department of Internal Medicine, Kawasaki, Japan; 6Graduate School of Medical Science, Kanazawa University, Department of Internal Medicine, Kanazawa, Japan; 7Tenri Hospital, Department of Endocrinology, Tenri, Japan; 8Saiseikai Yokohama-shi Tobu Hospital, Department of Diabetes and Endocrinology, Yokohama, Japan; 9National Hospital Organization Kyoto Medical Center, Department of Endocrinology and Metabolism, Kyoto, Japan; 10International University of Health and Welfare School of Medicine, Department of Public Health, Narita, Japan; 11Ijinkai Takeda General Hospital, Endocrine Center; 12National Center for Global Health and Medicine, Division of Endocrinology, Tokyo, Japan
Objective: Osteoporosis and osteopenia (OS/OP) are frequent in patients with cortisol-producing adrenal adenomas (CPA) associated with severity of cortisol excess (CE). However, the relationship between OS/OP and CE severity considering sex differences is unknown.
Patients and Methods: This was a retrospective cross-sectional observational study conducted as a part of the Advancing Care and Pathogenesis of Intractable Adrenal Disease in Japan (ACPA-J) study, which was based on a registration system for a cohort of patients with adrenal tumors. A total of 237 patients aged 20 to 90 who were diagnosed with mild autonomous cortisol secretion (MACS) and overt Cushing’s sindrome (CS) originated from CPA between January 2006 to December 2015 in 10 referral centerswere included in the study. MACS was defined by 1-mg overnight dexamethasone suppression test (DST) cortisol level >1.8 μg/dL (50 nmol/l). OS was defined by less than −2.5 SD of the bone miniral density (BMD) T-score obtained from the lumbar spine or femoral neck, fragility fractures, and medication for osteoporosis. OP was defined as a value of −2.5 SD < BMD T-score < −1.7 SD, without a history of fragility fracture and medication for osteoporosis.
Results: In total,112 of 237 patients, who were predominantly female (P<0.001) and had lower BMI (P=0.013), had OS/OP. Patients with OS/OP was significantly affected by CE (P<0.01) than those without. The adjusted odds ratio (OR) for predicting OS/OP was obtained in multivariate logistic regression analysis. Clinical measures of CE, 1-mg DST cortisol levels, were positively associated with OS/OP in total cases (OR 1.124, 95% CI: 1.070–1.181, P<0.001) and the cases with MACS (OR 1.156, 95%CI: 1.046–1.278, P=0.005). A cutoff value of 1-mg DST cortisol level >5.0 μg/dL was associated with OS/OP differently between men and women. OS/OP risk in men with MACS was significantly affected only by 1-mg DST cortisol levels (OR 1.221, 95%CI: 1.027–1.452, P=0.024). However, multivariate logistic regression analysis suggested that OS/OP risk in women with MACS was significantly affected by 1-mg DST cortisol levels (OR 1.129, 95% CI: 1.005–1.267, P=0.041) and age (OR 1.047, 95% CI: 1.006–1.090, P=0.024).
Conclusions: CE severity in CPA is positively associated with OS/OP. However, the associated factors of OS/OP in the patients with MACS are different between men and women.
Funding Statement: This study was supported by AMED, Japan (Grant Number JP17ek0109122 and JP20ek0109352) and National Center for Global Health and Medicine, Japan (27-1402, 30-1008 and 21A1015).
Volume 81
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more