ea0081s5.1 | Organ crosstalk in metaflammation | ECE2022
Mandrup-Poulsen Thomas
Innate immunity contributes to inducing functional inhibition and apoptosis of pancreatic beta-cells in the pathogenesis of both Type 1 diabetes (T1D) and Type 2 diabetes (T2D). The past four decades has provided overwhelming circumstantial evidence from in vitro studies and animal models that innate immune cells and cytokines are key effectors in beta-cell killing. Pro-inflammatory cytokines activate signaling pathways that reprogram the beta-cell transcriptome and proteome, ...