Endocrine Abstracts

My research focuses on the long-term consequences of pituitary diseases, and on the effects of stress hormones on the central nervous system (CNS) in specific. This has elucidated long-term effects of hormone excess on the CNS, as well as on other organs that affect stress-resilience, and consequently, general well-being and quality of life. This profoundly affects our understanding of the biological effects of stress hormone excess on the CNS, and on the care for patients with specific rare endocrine conditions. Endocrine tumours are characterized by low incidence, genetic predisposition (either isolated or as manifestation of a hereditary tumour syndrome), abnormal hormone secretion and expression of hormone receptors, specific genetic patterns, and generally slow growth. The special biology provides unique opportunities for systems biology and for development of targeted therapies. The complexity precludes that the diagnosis and treatment modalities fit in standard concepts of care, and the low prevalence implicates that screening and clinical decision making is very important. The installation of the European Reference Networks formed the foundation to improve quality and safety and access to highly specialized health care across Europe for patients affected by rare, or low prevalence and complex conditions. The European Reference Network on Rare Endocrine Conditions (Endo-ERN) covers specific expertise from birth to senescence and provides equal responsibilities for patient representatives and health care providers. The scope and mission of Endo-ERN is complex but ultimately will thrive toward reducing health care inequalities across Europe.