ECE2022 Poster Presentations Thyroid (136 abstracts)
Female papillary thyroid cancer survivors are at increased risk of hyperproliferative pathology of the reproductive system
Tetiana Tatarchuk 1 , Mykola Tronko 2 , Panagiotis Anagnostis 3 , Liudmyla Kalugina 1 , Natalia Pedachenko 4 , Anna Danylova 1 & Tetiana Kuchmenko 2
1State Institution “Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine“, Kiev, Greece; 2State Institution “V.P. Komisarenko Institute of Endocrinology and Metabolism”, Kiev, Ukraine; 3Aristotle University of Thessaloniki, Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Thessaloniki, Greece; 4Shupik National Healthcare University of Ukraine, Obstetrics, Gynecology and Gynecology Department, Kiev, Ukraine
Purpose: Thyroid cancer (TC) is the most common endocrine cancer worldwide, affecting mainly women of the reproductive age. However, no data exist with regard to its association with endometrial or uterine disorders. The aim of this study was to assess the risk of hyperproliferative pathology of the reproductive system in female TC survivors.
Methods: This was a cross-sectional study in female patients, aged 20-45 years, diagnosed with papillary TC (PTC) during the period 1994-2018. Age-matched females with normal thyroid structure served as controls.
Results: One-hundred and sixteen patients (mean age 36.7±61 years) and 90 age-matched controls were included. PTC survivors demonstrated an increased risk for adenomyosis [odds ratio (OR) 2.5, 95% confidence interval (CI) 1.3-4.8] and endometrial hyperplasia (OR 3.9, 95% CI 1.1-14.3), compared with controls. The risk for adenomyosis was higher after the ten post-operative years (OR 5.3, 95% CI 2.29- 12.05) than during the first 5-10 years (OR 2.3, 95% CI 1.02-5.10) and increased with the number of RAI courses and the degree of TSH suppression. The risk of endometrial hyperplasia was most evident during the first five years post-thyroidectomy (OR 6.0, 95% CI 1.4-25.5), especially in patients with TSH <0.1 mU/l (OR 6.8, 95% CI 1.4-33.28) No difference in uterine leiomyomas or endometrial polyps was found between PTC survivors and controls.
Conclusions: Female PTC survivors are at increased risk of endometrial hyperplasia and adenomyosis compared with those with normal thyroid structure.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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