Endocrine Abstracts

Subclinical hypothyroidism (SCH) represents a mild or compensated form of primary hypothyroidism. Although the relationship between SH and lipid profile have been reported in several studies, the results are conflicting. The objective of the present study is to assess dyslipidemia among patients with SCH. Our study included 107 patients vs 108 sex matched controls. Clinical information and medical history were obtained through a questionnary from all SCH patients and normal control subjects. Blood samples were collected and analyzed for thyroid-stimulating hormone (TSH), free thyroxine (FT4), total cholesterol (T-Chol), serum triglycerides (STG), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C). Results: average CT and LDL-C were significantly higher in patients respectively: 1.91±0.385 vs 1.77±0.294 (IC 95% 1.84P=0.02), and 1.19-0.341 vs 1.09 -0.258 (P=0.01). The average value of TG was higher in patients 1.23±0.69 Vs 1.14±0.527 (IC 95% 1.10)but the difference was not significantP=0.28. No correlation was found between TSH and lipidic parameters. Our study concluded that SCH is associated with elevated CT and LDL −CT. Therefore the assessment of lipidic parameters is highly recommended in theses patients