ECE2022 Poster Presentations Reproductive and Developmental Endocrinology (61 abstracts)
Age- and body mass index-adjusted association between insulin sensitivity and risk factors for cardiovascular disease in polycystic ovary syndrome
Małgorzata Kałużna 1 , Tomasz Krauze 2 , Pola Kompf 1 , Katarzyna Ziemnicka 1 , Wykretowicz Andrzej 2 , Marek Ruchala 1 & Przemyslaw Guzik 2
1Poznan Univeristy of Medical Sciences, Department of Endocrinology, Metabolism and Internal Diseases, Poznan, Poland; 2Poznan Univeristy of Medical Sciences, Department of Cardiology - Intensive Therapy, Poznan, Poland
Introduction: Impaired insulin sensitivity accompanies polycystic ovary syndrome (PCOS). Women with PCOS are usually at risk of premature cardiovascular disease, which increases with age and body weight. We studied the link between insulin sensitivity measured by the Matsuda Insulin Sensitivity Index (MISI) adjusted to body mass index (BMI) and age in otherwise healthy PCOS women.
Methods: 250 adult women with PCOS of reproductive age (18-43 years old) underwent measurements of MISI, lipid profile, resting heart rate, peripheral and central systolic and diastolic blood pressure. Patients were divided into tertiles of MISI (T1 (<4.74), T2 (4.74-8.35) and T3 (>8.35), respectively). Their data were compared by the Analysis of Covariance (ANCOVA) adjusted for patients’ BMI and age. Only the results with a P-value <0.05 are shown as Estimated Marginal Means +/- Standard Error in the following order: T1, T2 and T3.
Results: Better insulin sensitivity (patients with higher MISI values) was associated with lower plasma concentration of total cholesterol (188.2+/-3.8, 175.3+/-3.5 and 176.2+/-3.6 mg/dl), low-density lipoprotein cholesterol (106.0+/-3.4, 93.6+/-3.1 and 91.8+/-3.2 mg/dl), triglycerides (96.3+/-5.3, 77.5+/-4.8 and 76.2+/-5.0 mg/dl), and resting heart rate (76.9+/-1.5, 73.1+/-1.4 and 70.0+/-1.4 beats/minute) independent of age and BMI. Similar associations were not found for high-density lipoprotein cholesterol, peripheral and central systolic and diastolic blood pressure.
Conclusions: A less atherogenic lipid profile and lower heart rate, regardless of the effects of age and BMI, are observed in PCOS women with better insulin sensitivity. The clinical meaning of these findings requires further studies.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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