ECE2022 Poster Presentations Reproductive and Developmental Endocrinology (61 abstracts)
The effect of gastric sleeve resection on menstrual pattern and ovulation in premenopausal women with class III-IV obesity
Tetiana Tatarchuk 1 , Ivan Todurov 2 , Panagiotis Anagnostis 3 , Tetiana Tutchenko 1 , Natalia Pedachenko 4 , Marina Glamazda 1 , Natalia Koseii 1 & Svetlana Regeda 1
1Institute of Pediatrics, Obstetrics and Gynecology of the Academy of Medical Sciences of Ukraine, Kiev, Ukraine; 2Center for Innovative Medical Technologies, Academy of Sciences of Ukraine, Kiev, Ukraine; 3Aristotle University of Thessaloniki, Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Thessaloniki, Greece; 4Department of Obstetrics, Gynecology and Perinatology, P.L. Shupik National Healthcare University of Ukraine
Purpose: Bariatric surgery is very efficacious in treating severe obesity. However, its effect of menstruation and ovulation is currently unknown. The purpose of this study was to assess the effect of gastric sleeve resection (GSR) on menstrual pattern in women with stage III-IV obesity and ovulatory dysfunction compared with conventional management.
Methods: This was a prospective, multicentre, non-randomized trial, in premenopausal women, who fulfilled the criteria for gastric sleeve resection (GSR). Both women with and without polycystic ovary syndrome (PCOS) were evaluated at three, six, nine, 12 and 15 months post-surgery.
Results: Menstrual cycle irregularities were identified in 122 severely obese women (60 with PCOS; 62 non-PCOS). The % total weight loss was greater with GSR than with conventional management (33.4% vs. 3.6% in PCOS; 24.8% vs. 3.6% in non-PCOS, respectively). Intermenstrual interval was shortened towards normal length (≤35 days) both in PCOS and non-PCOS GSR groups, by the 6th and 12th post-surgical month, respectively. Furthermore, ovulation at six months was achieved in 63.6% of PCOS and 45% of non-PCOS subjects post-GSR, which was higher than in controls (11.1% and 13.6%, respectively; P<0.05). This percentage rose to 75.7% and 81.8% at 12 and 15 months in PCOS, respectively, but not in the non-PCOS group (55% and 52.5%, respectively; P<0.05).
Conclusions: Weight reduction after GSR improved menstrual irregularity towards normality in women with severe obesity. Ovulation dysfunction was also resumed in more than half of these patients at 6-15 months. These effects were more evident in women with PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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