ECE2022 Poster Presentations Reproductive and Developmental Endocrinology (61 abstracts)
Cardiometabolic risk factors and diabetes mellitus are related with the severity of menopausal symptoms in middle-aged women
Elena Armeni 1 , Stylianos Kopanos 1,2 , Eleni Verykouki 3 , Areti Augoulea 1 , Stavroula A. Paschou 1 , Demetrios Rizos 4 , George Kaparos 5 , Makarios Eleftheriades 1 , Anna-Bettina Haidich 3 , Dimitrios Goulis 2 , Nikolaos Vlahos 1 & Irene Lambrinoudaki 1
1National and Kapodistrian University of Athens, 2 nd Department of Obstetrics and Gynecology, Aretaieio Hospital, Athens, Greece; 2Unit of Reproductive Endocrinology, Medical School, Aristotle University of Thessaloniki, 1st Department of Obstetrics and Gynecology, Thessaloniki, Greece; 3Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, University Campus, Department of Hygiene, Social-Preventive Medicine and Medical Statistics, Thessaloniki, Greece; 4National and Kapodistrian University of Athens, Hormonal Laboratory, Aretaieion Hospital, Athens, Greece; 5National and Kapodistrian University of Athens, Aretaieion Hospital, Biochemical Laboratory, Athens, Greece
Background: Both surgical and spontaneous menopause are associated with increased cardiovascular disease (CVD) risk. Recent evidence reported that clusters of menopausal symptoms are associated with accumulation of cardiometabolic risk factors. Climacteric symptoms are also known to be affected by lifestyle parameters, ethnicity, the geographical location as well as by the overall health status at the time of the menopausal transition.
Aim: This study aimed to evaluate the association between menopausal symptoms, and lifestyle as well as cardiometabolic risk factors, in a cohort of apparently healthy middle-aged women.
Methods: This study consisted of 2.793 peri- and postmenopausal women (menopausal-age ≤ 15 years), not on menopausal hormone therapy, retrieved from the outpatient Menopause Clinic of the 2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Greece. We assessed demographic and athropometric parameters (including body mass index, BMI), and obtained fasting blood samples for evaluation of biochemical/hormonal data. The severity of menopausal symptoms was evaluated by the Greene Climacteric scale (GCS).
Results: Mixed effect models showed that the total GCS-score associated with BMI (b=0.12, 95%CI: 0.04 to 0.20), diagnosis of type 2 diabetes (T2DM, b=2.10, 95%CI: 0.06 to 4.15), older age at menopause (menopausal age > 7 years vs 2 to 7 years, b=-1.24.95% CI: -2.17 to -0.33). Physical GCS score associated with BMI (b=0.06, 95%CI: 0.03 to 0.09), central obesity (b=0.18, 95%CI: 0.02 to 0.34), menopausal status (2 to 7 years vs > 7 years after the final menstrual period vs. perimenopause, b=-0.36, 95%CI: -0.59 to -0.13 and b=-0.65, 95%CI: -0.97 to -0.34, respectively). Psychological GCS-score associated with values of BMI (b=0.06, 95% CI: 0.00 to 0.11). All previous GCS-scores associated negatively with age. Vasomotor GCS-score associated negatively with menopause-age > 7 years vs younger menopausal age. Poisson mixed models showed that GCS-sexual score associated with a younger menopausal age (menopause age 2 to 7 years vs > 7 years, incidence rate ratio (IRR)=1.53, 95%CI: 1.21 to 1.94), central obesity (IRR=1.18, 95%CI: 1.00 to 1.39), smoking, diastolic blood pressure, age.
Conclusions: The results of this study indicate that the severity of menopausal symptoms is associated with obesity, smoking and T2DM, in a large sample of peri- and postmenopausal women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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