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Endocrine Abstracts (2022) 81 P187 | DOI: 10.1530/endoabs.81.P187

ECE2022 Poster Presentations Reproductive and Developmental Endocrinology (61 abstracts)

Overall impact of gender affirming hormone therapy: the portuguese experience

Miguel Saraiva 1 , Rafael Santos 2 , Zélia Figueiredo 3 , Carolina Lemos 4 & Isabel Palma 1


1Centro Hospitalar Universitário do Porto - Hospital de Santo António, Endocrinology, Diabetes and Metabolism, Porto,; 2Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto; 3Hospital de Magalhães Lemos; 4i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto


Introduction: The prevalence of Transgender individuals seeking gender affirming hormone therapy (GAHT) has been increasing. This therapy has been known to be highly effective in the treatment of gender dysphoria and enhancing mental health in this population.

Aim: To evaluate the overall impact of GAHT on self-esteem, well-being and social/familial relations in the Portuguese adult transgender population

Methods: Cross-sectional study conducted in March 2021. Data collected through an online questionnaire that was delivered to adult transgender people living in Portugal who had been under GAHT for at least one year. To answer some of the items on the questionnaire, an ordinal scale ranging from 0 (worst result) to 6 (best result) was used.

Results: A total of 142 individuals (Group T) answered the questionnaire: 101 under masculinizing GAHT (Group M) and 41 under feminizing GAHT (Group F), with a median age of 25.0(21.0−33.0) years. The overall satisfaction with GAHT was evaluated with a median of 5.0 (5.0-6.0) points, with no differences between subgroups (P=0.681).

Table 1
VariableGroup TGroup MGroup F
NMedian (P25-P75)PnMedian (P25-P75)PnMedian (P25-P75)P
Self-esteem Before After
114

1.5 (1.0 − 2.0)
1.5 (1.0 − 2.0)

<0.001

87

1.0 (0.0 − 2.0)
5.0 (4.0 – 6.0)

<0.001
27 2.0 (1.0–2.0)
5.0 (4.0–6.0)

<0.001
Body wellbeing
Before
After

114

1.0 (0.0 – 2.0)
5.0 (4.0 – 5.0)

<0.001

87

1.0 (0.0 – 2.0)
4.0 (3.0 – 5.0)
<0.001 27 1.0 (0.0–2.0)
5.0 (4.0–6.0)

<0.001
Suicidal ideation
Before
After

114

3.0 (1.0 – 5.0)
5.0 (2.0 – 6.0)

<0.001

87

3.0 (1.0 – 5.0)
5.0 (3.0 – 6.0)
<0.001 27 3.0 (1.0–5.0)
3.0 (2.0–6.0)
0.406
Social relations
Before
After

113

3.0 (1.0 – 4.0)
5.0 (3.0 – 6.0)

<0.001

86

3.0 (1.0 – 5.0)
5.0 (3.0 – 6.0)
<0.001 27 3.0 (0.0–4.0)
5.0 (3.0–6.0)
0.003
Familial relations
Before
After

114

3.0 (1.0 – 4.3)
4.0 (3.0 – 5.0)

<0.001

87

3.0 (2.0 – 5.0)
4.0 (3.0 – 5.0)

<0.001
27 3.0 (2.0–4.0)
5.0 (3.0–5.0)
0.019

Discussion: This study reinforces that transgender people report high grades of satisfaction with both the physical and psychological effects of GAHT. This therapy seems to significantly enhance self-esteem, body wellbeing and social/familial relations and to reduce suicidal ideation, having an overall great impact on the quality of life of transgender people.

Volume 81

European Congress of Endocrinology 2022

Milan, Italy
21 May 2022 - 24 May 2022

European Society of Endocrinology 

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