ECE2022 Poster Presentations Reproductive and Developmental Endocrinology (61 abstracts)
Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men highlights new potential physiological functions of AMH on FSH secretion and sperm motility
Hamza Benderradji 1,2 , Barbotin Anne-Laure 2,3 , Leroy-Billiard Maryse 4 , Prasivoravong Julie 1 , Marcelli François 1 , Decanter Christine 4 , Robin Geoffroy 1 , Mitchell Valérie 1 , Rigot Jean-Marc 1 , Bongiovanni Antonino 5 , Sauve Florent 2 , Buée Luc 2 , Maurage Claude-Alain 2,6 , Cartigny Maryse 7 , Villers Arnauld 1 , Prevot Vincent 2 , Catteau-Jonard Sophie 2,4 , Sergeant Nicolas 2 , Giacobini Paolo 2 , Pigny Pascal 8,9 & Leroy Clara 1,7
1University of Lille, CHU Lille, Department of Andrology, Urology and Renal Transplantation, Lille, France; 2University of Lille, Inserm, CHU Lille, Lille Neuroscience & Cognition, UMR-S1172, Lille, France; 3University of Lille, CHU Lille, Department of Reproductive Biology-Spermiology-CECOS, LILLE, France; 4University of Lille, CHU Lille, Department of Endocrine Gynecology and Reproductive Medicine, Lille, France; 5University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, US 41 - UMS 2014-PLBS, BioImaging Center Lille, Lille, France; 6University of Lille, CHU Lille, Department of Pathological Anatomy, Lille, France; 7University of Lille, CHU Lille, Department of Pediatric Endocrinology, DevGen, Reference Centre for Genital Development Abnormalities, Lille, France; 8Department of Biochemistry & Hormonology, Lille, France; 9University of Lille, CHU Lille, Inserm, UMR-S 1277, Lille, France
Background: Few studies to date have attempted to measure serum anti-Müllerian hormone (AMH) levels in adult men, and solid references ranges have not yet been defined on a large cohort.
Objective: In this study, we aimed to first establish the reference ranges for serum AMH and AMH-to-total testosterone ratio (AMH/tT) in adult males. Secondly, we investigated the relationship between serum AMH and both reproductive hormones and semen parameters.
Methods: This single-center retrospective study included 578 normozoospermic adult men. Serum AMH concentrations were determined with an automated sandwich chemiluminescent immunoassay.
Results: The median serum AMH was 43.5 pmol/l. The 2.5th and 97.5th percentile values for serum AMH and AMH/tT were 16.4 pmol/l − 90.3 pmol/l, and 0.45 − 3.43, respectively. AMH was positively correlated with inhibin B and sperm concentration, and negatively correlated with age, FSH and progressive sperm motility. Interestingly, using immunofluorescence, we documented for the first time that AMH type-II receptor (AMH-R2) is expressed in ejaculated human spermatozoa and gonadotrophic cells in postmortem pituitaries.
Conclusions: A new age-specific reference range for serum AMH and AMH/tT was established. Moreover, AMH-R2 expression in human spermatozoa and gonadotrophic cells, together with the relationship between serum AMH levels and sperm motility or mean FSH levels, highlight new potential functions of AMH in regulating sperm motility or FSH secretion in adult men.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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