ECE2022 Poster Presentations Late-Breaking (41 abstracts)
Regulatory B cells involvement in autoimmune phenomena occurring in pediatric graves’ disease patients.
Artur Bossowski 1 , Kamil Grubczak 2 , Aleksandra Starosz 2 , Karolina Stożek 3 , Filip Bossowski 4 & Marcin Moniuszko 5
1Medical University in Bialystok., Department.of Pediatric Endocrinology and Diabetes, with a Cardiology Unit, Bialystok, Poland; 2Medical University in Bialystok, Department of Regenerative Medicine and Immune Regulation, Bialystok, Poland; 3Medical University in Bialystok, Dep. Of Pediatric Endocrinology and Diabetes, with a Cardiology Unit, Bialystok, Poland; 4Medical University in Bialystok, Dep of Pediatric, Endocrinology and Diabete, with a Cardiology Unit, Bialystok, Poland; 2Medical University in Bialystok, Department of Regenerative Medicine and Immune Regulation, Bialystok, Poland
Graves’s disease is the most common type of autoimmune hyperthyroidism. Numerous studies indicate different factors contributing to the onset of the disease. Despite years of research, the exact pathomechanism of Graves’ disease still remains unresolved, especially in the context of immune response. B cells can play a dual role in autoimmune reactions, on the one hand, as a source of autoantibody mainly targeted in the thyroid hormone receptor (TSHR) and, on the other, by suppressing the activity of proinflammatory cells (as regulatory B cells). To date, data on the contribution of Bregs in Graves’ pathomechanism, especially in children, are scarce. Here, we investigated the frequencies of Bregs before and during a methimazole therapy approach. We reported higher Foxp3+ and IL-10+ Breg levels with CD38- phenotype and reduced numbers of CD38 + Foxp3 + IL-10+ in pediatric Graves’ patients. In addition, selected Breg subsets were found to correlate with TSH and TRAb levels significantly. Noteworthy, certain subpopulations of Bregs were demonstrated as prognostic factors for methimazole therapy outcome. Our data demonstrate the crucial role of Bregs and their potential use as a biomarker in Graves’ disease management.
Volume 81
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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