Endocrine Abstracts

Aim: To evaluate adiponectin and resistin levels and their relationship with various biochemical and metabolic and atherogenic parameters markers, as well as their correlation, and to investigate its contribution in pathogenesis of insulin resistance in cohort women with PCOS and of insulin resistance as well as in non-insulin resistant women with PCOS. Methods: This study was designed as a cross-sectional and involves 80 premenopausal women. Of these patients, 63 females have met the criteria for PCOS (59 insulin resistant, 28 non-insulin resistant). We assessed anthropometric indices of obesity –waist and hip circumference, waist to hip ratio, serum glucose, insulin, total cholesterol, HDL-cholesterol, triglycerides, FSH, LH, E2, testosterone, adiponectin and resistin. Body mass index, waist to hip ratio, HOMA-IR, LDL-cholesterol, and adiponectin to resistin ratio were calculated. Results: Insulin resistant PCOS woman had significantly lower levels of adiponectin compared to non-insulin resistant PCOS women, and controls. Resistin levels were higher in IR-PCOS, but without statistical significance. Adiponectin showed significant positive correlation with LH, HDL-C, and negative correlation with BMI, insulin, HOMA-IR and triglycerides. Resistin correlated positively with BMI and WC. A/R was significantly higher in insulin resistant PCOS women compared to non-insulin resistant and control women. Conclusions: These results suggest that PCOS women were at higher metabolic and atherogenic risk as compared to the healthy women, and also more pronounced in the insulin-resistant group. Correlations of adipokines with insulin resistance suggest their involvement of adipokines in modulation of insulin action in PCOS women.