ECE2022 Poster Presentations Late-Breaking (41 abstracts)
Changes in acromegaly presentation and treatment over a three-decade period
Charlotte Aagaard 1 , Amanda S Christophersen 1 , Susanne Finnerup 1 , Christian Rosendal 1 , Peter Vestergaard 1,2 , Jesper Karmisholt 1 , Eigil H Nielsen 1 & Jakob Dal 1
1Aalborg University Hospital, Endocrinology, Aalborg, Denmark; 2Steno Diabetes Center, North Jutland, Aalborg, Denmark
Objective: To study time-dependent changes in the prevalence and patient characteristics of acromegaly, as well as to access the impact of changes in treatment on disease control.
Methods: A total of 107 patients with acromegaly were identified by healthcare registries and subsequently validated by patient chart review over a three-decade period (1992-2021).
Results: The prevalence of acromegaly significantly increased throughout the study period (R2 =0.94, P<0.001) and was 122 cases/106 in 2021 whereas the annual incidence was constant 4.6 cases/106. The age at the first sign of acromegaly and the age at diagnosis significantly increased during the study period, whereas GH and IGF-I decreased. Incidentalomas constituted 32% of all cases diagnosed with acromegaly in the last decade. Primary surgery was used in 93% of all cases, and reoperations decreased from 24% to 10% during the three decades. The use of somatostatin analogues (SSA, 21%-48%) and second-line medical treatment (4%-20%) increased with a concomitant improvement of biochemical disease control (58%-91%).
Conclusion: The prevalence of acromegaly is higher than previously reported and the clinical presentation has shifted towards a milder phenotype. Modern treatment of acromegaly enables individualized treatment and disease control in the majority of patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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