Endocrine Abstracts

Introduction: Early spontaneous miscarriage is common in diabetic women and has an unknown mechanism. This rate of spontaneous miscarriage is directly correlated to the glycemic control at the beginning of pregnancy.

Objective: To assess the frequency of spontaneous miscarriage in women with diabetes.

Patients and Method: This is a retrospective study including 50 diabetic women followed at department C of the National Institute of Nutrition of Tunis.

Results: The average age of our patients was 30±7 years. The average duration of diabetes was 9±7 years. Our population included: 46% type 2 diabetes, 42% type 1 diabetes and 12% gestational diabetes. the mean glycated hemoglobin (HbA1c) was 8.2%. The frequency of spontaneous miscarriage was 34% with a higher incidence in type 2 diabetics:82% vs 18% in type 1 diabetics. Patients with a history of spontaneous miscarriage had less controlled diabetes than others (mean hemoglobin glycated hemoglobin : 8.8% vs 7.9%).

Conclusions: Given the high frequency of spontaneous miscarriage in diabetic women, the practitioner is encouraged to provide adequate management of diabetic women before pregnancy.