Endocrine Abstracts

Objective: Having a psychiatric disorder may increase the risk of developing type 2 diabetes (T2D) and we aimed to determine whether young adults with a psychiatric disorder have an increased risk of developing T2D.

Research Design and Methods: We conducted a nationwide cohort study to evaluate the association of different psychiatric disorders with the risk of T2D in the young population. Records of 6.457.991 adults aged 20−39 years without a history of T2D were retrieved from database of the South Korean National Health Insurance between 2009 and 2012. Service and followed up for incident T2D cases until December 2018. Five categories of psychiatric disorders were included: schizophrenia, bipolar disorder, depressive disorder, anxiety disorder, and insomnia. Hazard ratios (HRs) and confidence interval (CI) for developing T2D were estimated using Cox proportional hazards regression models.

Results: Over a median follow-up period of 7.59 years (range 6.47-8.23), a total of 122.603 patients with newly diagnosed T2D were identified. Cumulative incidence of T2D significantly increased with all five psychiatric disorders (P <0.001). The multivariable-adjusted HRs was 1.146 (95% CI 1.106−1.189) for depression; 1.517(95% CI 1.319−1.745) for schizophrenia; 1.594 (95% CI 1.413−1.798) for bipolar; 1.226 (95% CI 1.183−1.271) for insomnia; and 1.134 (95% CI 1.07−1.62) for anxiety disorder.

Conclusions: All five psychiatric disorders were associated with increased risk of incident T2D in the young population. There was most significant increased risk of T2D in young adults with schizophrenia and bipolar disorders.