Endocrine Abstracts

The purpose of the study is to assess the relationship of the level of growth factor level (VEGF) in blood serum with retinal microcirculation indicators according to oct-A data in patients with type 2 diabetes mellitus (DM2), with different stages of diabetic retinopathy (DR).

Material and research methods: 252 people were examined (n=504), of which 168 patients with type 2 type and 84 practically healthy persons. The main group (I; n=174) with DM2, divided into subgroups, depending on the stage of DR: Easy non-proliferative DR (NDR), moderate NDR, severe NDR and PDR. As a comparison group (II; n=162), patients are included without clinical manifestations of others (III; n=168) - the control group was almost healthy faces without significant ophthalm and somatic pathology. All patients conducted a standard and specialized ophthalmological examination. Optical coherent tomography in the angio mode is made using an Optical Cherent Tomograph RevOFC with an angiography module with a 3×3 mm scan area. The level of VEGF in serum was evaluated by solid-phase immunoassy analysis using Quantikine ELISA sets.

Results: VEGF levels in blood serum in the studied groups showed a significant tendency to increase from 100.47±49.66 pg/ml (control group) to 463.18±78.69 pg/ml PDR (P<0.001). The increase in the VEGF indicator in the blood serum was revealed before the DR occurred clinically 137.29±84.45 pg/ml (comparison group). The average levels of VEGF at easy NDR (177.07±35.37), moderate NDR (255, 29±65.67), heavy NDR (424.34±56.67) also showed a tendency to increase. It was statistically established that the difference between all groups was significant (P<0.05). It was found that the VEGF level correlates with Oct-A (P<0.05).

Conclusions: The earliest marker of DR is to increase the average level of VEGF growth factor in the blood serum of patients 137.29±84.45 Pg/ml, which comes before the appearance of a clinical picture