ECE2022 Poster Presentations Diabetes, Obesity, Metabolism and Nutrition (202 abstracts)
Threshold value of galectine-3 in a Tunisian diabetic population
Dayssem Khelifi 1 , Ibtissem Ben Nacef 1 , Kahena Bouzid 2 , Imen Rojbi 1 , Youssef Lakhoua 1 , Nadia Mchirgui 1 & Karima Khiari 1
1Charles Nicolle University Hospital, Endocrinology’s Department, Tunisia; 2Charles Nicolle University Hospital, Clinical Biochemistry Department, Tunisia
Background and aims: Plasma Galectin-3 (Gal-3), mediator of fibrogenesis and inflammation, has been implicated in many diseases. Particularly in diabetics, this lectin directly mediates transdifferentiation in collagen-producing cells thus leading to fibrosis of target organs and accelerating the development of complications. The objective of our study was to determine a cut-off value for Gal-3 in our population.
Methods: We conducted a cross-sectional, analytical study including 260 type 2 diabetic patients. For statistical purposes, we solicited a second control group of non-diabetic patients. For the determination of the discriminating threshold of the quantitative variable, we established ROC curves (Receiver Operating Characteristics).
Results: In our series, the mean serum Gal-3 level in our diabetic patients was in the order of 14.24 ng/ml ± 7.32 (range: 3.30 and 69.30 ng/ml). The median concentration was 12.4 ng/ml. The mean Gal-3 value in the control group was 11.80 ng/ml ± 3.75 (range: 4.4 and 25.5 ng/ml) and a median of 10.9 ng/ml. A statistically significant increase in serum Gal-3 (P<0.001) in the diabetic group was observed. We carried out an ROC curve which allowed us to define a value of Gal-3 at 11.25 ng/ml as the best threshold of sensitivity and specificity. The area under the ROC curve was 0.61 (Confidence Interval: CI95 [0.55–0.67], P=0.001).
Conclsions: The level of Gal-3 differs from study to study. This could be explained by the fact that the plasma levels of Gal-3 are influenced by socio-demographic, anthropometric, clinical and biological factors. Hence the need to determinate a specific serum threshold for each population.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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