Endocrine Abstracts

Introduction: Hyperuricemia is associated with increased cardiovascular mortality and morbidity hence the interest in screening for hyperuricemia in the type 2 diabetic population.

Objective: To investigate the association between hyperuricemia and degenerative complications in type 2 diabetics.

Patients and Methods: This is a retrospective study including 130 patients followed in the C department of the National Institute of Nutrition in Tunis.

Results: The mean age of our patients was 61±11 years, with a sex ratio M/F=0.63. The average duration of diabetes was 14±8 years. Obesity was present in 63.2% of patients. The incidence of hyperuricemia was 47.1% with a higher incidence in women: 54.4% of these patients were women vs 45.6% of men. In this population, microangiopathic and macroangiopathic degenerative complications were noted in 80.8% and 45% of cases respectively. For macroangiopathic complications, coronary artery disease topped the list with a frequency of 43.1%, followed by obliterative arteriopathy of the lower limbs with a frequency of 25.5% and finally stroke with a frequency of 3.9%. For microangiopathic complications, diabetic retinopathy was noted in 56.9% of cases. The frequency of diabetic nephropathy was 50%, of which 26.3% were at the stage of renal failure. The frequency of diabetic neuropathy was 38.5%. This analysis showed that hyperuricemia was significantly associated with macroangiopathic complications (P=0.06) and microangiopathic complications (P=0.049).

Conclusion: Our study showed a significant association between hyperuricemia and degenerative complications of type 2 diabetes.