Endocrine Abstracts

Hyperuricemia is a high risk factor for atherosclerotic diseases such as CVD and carotid atherosclerosis, hypertension, type 2 diabetes mellitus (T2DM), metabolic syndrome (MS). There are complex interrelationships between hyperuricemia, T2DM, chronic kidney disease (CKD) and MS. The purpose of our study was to investigate the relationship between hyperuricemia, CKD, MS, and its components.

Materials and methods: 179 patients with T2DM were included. The baseline presence of components of metabolic syndrome as defined by the World Health Organization was determined. CKD was defined according to the guidelines by reduction of GFR below 60 ml/min/1.73 m2, with a minimum duration of 3 months or renal impairment lasting more than 3 months. Hyperuricemia was determined as serum uric acid level above 7 mg/dl in men and 6 mg/dl in women.

Results: Following the analysis of the studied group, out of the 179 cases, 131 were identified with hyperuricemia and 48 with normo-uricemia. The prevalence of hyperuricemia was 73%. The average age of the patients was 73 years. In patients with hyperuricemia, the mean values of SBP and DBP were statistically significant higher than in patients with normo-uricemia (P<0.003). Triglycerides had statistically significant higher values in the hyperuricemia group (P<0.005). The mean HDL-cholesterol value being statistically significant lower in the hyperuricemia group (P<0.01). Renal function evidenced by creatinine, blood urea nitrogen and GFR, was statistically significant lower in patients with hyperuricemia (P<0.001). There was statistically significant relation between hyperuricemia and albuminuria (P=0.008), as predictor of diabetic nephropathy.

Conclsions: Among diabetic patients with hyperuricemia, the prevalence of CKD, obesity, hypertension, MS and its components are statistically significantly higher than in patients with normo-uricemia.