ECE2022 Poster Presentations Diabetes, Obesity, Metabolism and Nutrition (202 abstracts)
The crosstalk between adiposity and bone: a potential role for SIRT1 and sclerostin
Rossella Tozzi 1 , Davide Masi 2 , Fiammetta Cipriani 2 , Maria Elena Spoltore 2 , Savina Contini 2 , Mikiko Watanabe 2 , Sabrina Basciani 2 , Carla Lubrano 2 , Lucio Gnessi 2 & Stefania Mariani 2
1Sapienza University of Rome, Molecular Medicine, Roma, Italy; 2Sapienza University of Rome, Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, Roma, Italy
Background and aim: Sirtuin1 (SIRT1) and sclerostin play important roles in adipose tissue and bone metabolism. SIRT1 pharmacological induction improves bone quality both in murine and human models and- as adiposity increases – its expression decreases both in peripheral tissues and blood. Sclerostin reduces osteoblasts’ differentiation and mineralization and is associated with DMT2, obesity and cardiovascular risk. We evaluated the circulating SIRT1 and sclerostin relationship with mass and quality of bone considering the degree of adiposity.
Materials and methods: 66 premenopausal women (16 underweight, 25 normal weight and 25 with obesity), aged <50 years, were enrolled. Plasma SIRT1, sclerostin, and DXA body composition [total-fat mass (FM), abdominal visceral adipose tissue, lean mass, trabecular bone score (TBS), lumbar spine and femoral neck-bone mineral density (BMD)] were assessed.
Results: The patients with obesity showed the lowest SIRT1 and TBS values and the highest sclerostin concentrations; BMD increased with FM and BMI and had an inverse association with SIRT1. Sclerostin was negatively correlated with SIRT1 (P=-0.37, P=0.002). When spine-BMD, femoral neck -BMD and TBS were standardized for BMI, a positive correlation with SIRT1 and a negative correlation with sclerostin were seen (P<0.005). In a regression analysis, sclerostin was the best independent, negative predictor for BMD and TBS, while SIRT1 directly predicted TBS (P<0.05).
Conclusion: Blood measurement of SIRT1 and sclerostin could represent a snapshot of the bone status that, taking into account the degree of adiposity, may reduce the interference of confounding factors in the interpretation of the bone health parameters.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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