ECE2022 Poster Presentations Calcium and Bone (68 abstracts)
Bone mineral density, trabecular bone score and vertebral fractures in acromegalic patients
Madalina Sorohan 1,2 , Ramona Dobre 3 , Ionela Baciu 2,3 , Simona Galoiu 1,2,2 , Roxana Dusceac 1,2 , Dan Niculescu 1,2 , Andra Caragheorgheopol 1 , Carmen Iordachescu 1 & Catalina Poiana 1,2
1CI Parhon National Institute of Endocrinology, Pituitary Pathology and Neuroendocrinology, Bucharest, Romania; 2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 3CI Parhon National Institute of Endocrinology, Bucharest, Romania
Background: Acromegaly is characterized by increased prevalence of fragility vertebral fractures. Nonetheless, there are no clear recommendations for prevention of acromegalic osteopathy. Both bone mineral density (BMD) and trabecular bone score (TBS) lack clear evidence as prognostic factors for vertebral fractures (VF).
Material and Methods: We performed an observational study on 31 acromegalic patients recruited prospectively. They were tested for alkaline phosphatase, 25 hydroxyvitamin D, parathormone, osteocalcin, the C-terminal telopeptide of type I collagen and total procollagen type 1 amino-terminal propeptide. Imaging techniques used were dual x-ray absorptiometry (DXA), TBS and antero-posterior and lateral x-ray scans of the dorsolumbar spine.
Results: They were characterized by normal BMD, partially degraded bone on TBS, 32.33% had VF on dorsolumbar x-ray and hypogonadism was present in 71% of subjects. Hypogonadal acromegaly subjects had significantly lower TBS (1.232±0.123 vs. 1.343±0.146, P=0.040) but higher T (P=0.029) and Z scores (P=0.004) at the femoral neck compared to eugonadal patients. Acromegalic patients with VF had significantly lower BMD at the femoral neck (0.901±0.137 vs. 1.013±0.131 g/cm2, P=0.037) and hip (0.883±0.109 vs. 1.036±0.121, P=0.002) and T score at the lumbar spine [-2.7 (IQR: -3.4- -0.6) vs. -1.2 (IQR: -1.9-0.1), P=0.047] compared to those without VF but with no differences in terms of TBS values.
Conclusion: Vertebral fractures in acromegaly patients associate with low BMD but not with TBS. However, TBS is significantly lower in these patients in the presence of hypogonadism. The use of BMD might still prove to be useful in the evaluation of acromegalic osteopathy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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