ECE2022 Poster Presentations Calcium and Bone (68 abstracts)
Weakening of short- and long-term verbal memory in patients with PHPT, evaluated by a neuropsychological approach
Federica Saponaro 1 , Gaspare Alfi 2 , Filomena Cetani 3 , Antonio Matrone 3 , Laura Mazoni 3 , Matteo Apicella 3 , Elisa Lai 2 , Marco Laurino 2 , Angelo Gemignani 2 & Claudio Marcocci 3
1Biochemistry Institute, Department of Pathology, University of Pisa, Pisa, Italy; 2Department of Pathology, University of Pisa, Pisa, Italy; 3Endocrinology Unit, University Hospital of Pisa, Pisa, Italy
Introduction and aims: Primary Hyperparathyroidism (PHPT) is a common endocrine disease associated with hypercalcemia and elevated or inappropriately normal serum levels of PTH. Among PHPT manifestations, neuropsychological symptoms have been described, including depression, anxiety, loss of memory, impaired cognition, with a wide range (3-50%) depending on the study population. Neuropsychological/ccognitive symptoms in patients with PHPT have been evaluated as part of quality of life (QoL) assessment, mainly using validated self-administered questionnaires, such as 36-Item Short Form Health Survey (SF-36), WHO-5 Well-being Index Survey (WHO-5), which lack specificity. This study aims to evaluate cognitive functions of patients with PHPT compared to a control population, using a standardized neuropsychological approach.
Methods: Observational, monocentric study on patients with PHPT and controls, in whom a standardized neuropsychological assessment, focused on attentive functions and memory abilities was performed by a trained psychologist.
Results: Patients (n=19) presented a mild PHPT, and mean age 53.8±11.45 years). Control population (n=24, mean age was 51.8±10.87 years) was enrolled among patients with differentiated thyroid cancer in remission (or without residual disease), without Hypoparathyroidism and in good control under levothyroxine therapy, who were followed by Endocrine Unit (University Hospital of Pisa). Patients with PHPT had significantly worse performance at Digit Span Forward (mean score 5.41±0.81 – 6.17±1.64; P-value <0.05) test that provides a measure of verbal short-term memory span and Story Recall Test that provides a measure of auditory-verbal long – term memory. Regarding Story Recall Test the worse performance was confirmed both in immediate (mean score 4.54±1.40 – 5.72±1.46 P-value <0.05) and delayed recall (4.37±1.30 – 5.44±1.51; P-value <0.05).
Conclusions: Patients with PHPT might present a weakening in verbal short – and long – term memory. Further studies are ongoing to evaluate other cognitive functions and to correlate cognitive testing with biochemical parameters.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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