Endocrine Abstracts

Background: Hypertension has a negative effect on the cardiovascular system, but the data are limited about the connection between non-dipper hypertension and inflammation in patients with type 2 diabetes (T2D) and without.

Aim: To study the effects of dipper and non-dipper hypertension with and without type 2 diabetes on inflammatory factors.

Methods: The cross-sectional study included 97 hypertensive patients (57 men) without type 2 diabetes and 85 hypertension patients with type 2 diabetes median age 56,5 (45.00 ÷ 63.70) years old. All patients had been on stable antihypertensive and anti-hyperglycemic therapy during the last three months and had target ambulatory blood pressure at the moment of inclusion to the study. Daily blood pressure monitoring was done to all patients with Heaco ABPM50 monitoring. Fasting glucose (FG), blood lipids, creatinine, uric acid, high sensitive C-reactive protein (hCRP), and interleukin 1 beta (IL-1B) were measured. Physical activity was assessed using the International Physical Activity Questionnaire. Data were analyzed with SPSS IBM 19.0.

Result: According to their night blood pressure, the patients were divided into dipper (n=84) and non-dipper (n=98). The mean of day and night systolic and diastolic blood pressure according to the group presented in table 1. The mean of hCRP in dipper patients without T2D was 7.7 ∓8.4 and IL-1b 2.3 ∓ 0.5 pg/ml, non-dipper hCRP 11.4∓6.7 mg/L (P=0.05) and IL-1b 2.2 ∓ 0.6 pg/mL (p>0.05). The mean of hCRP in dipper patients with T2D was 12.2∓7.9 mg/L and IL-1b 2.3 ∓ 0.5 and non-dipper hCRP 10.2 ∓5.5 (p>0.05) and IL-1b 2.7 ∓ 0.7 pg/mL (p>0.05).

Conclusion: Non-dipper hypertension patients without type 2 diabetes could be an additional risk factor of vascular inflammation. Patients with type 2 diabetes and hypertension have a higher inflammation level, independent of dipper status; future studies are needed.