Endocrine Abstracts

Background: Menopause has been related to a deficiency of bulk and an increment in fat mass. Testosterone treatment is being considered to further develop body organization in menopausal women. Notwithstanding, the portion reaction connections among testosterone and the progressions in body structure and muscle strength in women have not been set up. To decide the portion subordinate impacts of reviewed dosages of testosterone on body arrangement and muscle strength in precisely menopausal women.

Methods: 76 surgically menopausal women got a normalized estrogen routine during the 12-week altercation period and were then randomized to one of 5 gatherings to get week after week IM infusions of fake treatment (n=16), 3 (n=15), 6.25 (n=15), 12.5 (n=16) or 25 mg (n=14) testosterone enanthate for quite some time. Aggregate and free testosterone levels were estimated by LC-MS/MS and balance dialysis, individually. Slender weight (LBM) and fat mass were estimated utilizing DXA output and muscle strength was evaluated by one-redundancy most extreme technique at pattern and week 24.

Results: 76 women were randomized. A pattern, mean age was 53 yrs, BMI 30 kg/m², total testosterone 13.8 ng/dl and free testosterone 2.3 pg/ml. On-treatment nadir testosterone fixations were 15, 88, 107, 165 and 212 ng/dl at the 0, 3, 6.25, 12.5 and 25-mg portions, individually. Changes in LBM exceptionally corresponded with changes in testosterone focuses; the assessed between-individual contrast in LBM was 0.67 kg per 100 ng/dl change in testosterone (95% CI: 0.23, 1.11; P=0.003). There was a huge expansion in LBM in the 25-mg portion bunch (normal increment=1.7 kg, P=0.01). No huge changes in fat mass and leg press strength were seen.

Conclusion: Testosterone organization in precisely menopausal women was related to portion and fixation subordinate additions in LBM. Long haul randomized paths are expected to decide if clinically significant enhancements in different results can be accomplished securely with testosterone dosages that don’t deteriorate cardiovascular danger or incite virilization.