Endocrine Abstracts

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals, with elimination half-lives ranging from four to eight years. Experimental studies found PFAS able to interfere with thyroid hormone-binding proteins. During the first 20 weeks of gestation (GW), the fetus is reliant on placental transfer of maternal thyroid hormones, mainly free thyroxine (FT4). However, previous studies investigating associations between exposure to PFAS and thyroid hormone stat...

Perfluoroalkyl substances (PFASs) have been claimed as thyroid disrupting chemicals since the exposure to several PFASs was significantly associated with thyroid hormones derangements. Demographics such as sex, age, and disease status likely influence the associations between PFASs exposure and thyroid hormones since major hypothyroidism effects were observed among pregnant women and infants. This study aims to evaluate of the possible impact of legacy and new-generation PFAS ...

Androgen signaling is essential for male reproductive development and masculinization during fetal life. Developmental exposure to endocrine disrupting chemicals, not least those that disrupt androgen action, can lead to reproductive disorders such as cryptorchidism, hypospadias, and poor fertility. In rodent toxicity studies, as well as human epidemiological studies, a general biomarker for compromised fetal androgen signaling is a shorter anogenital distance (AGD) in male of...

Campania Region has been facing waste management crisis since 1980, characterized by urban, toxic and industrial waste illegal disposal, burying and incineration. Cadmium (Cd) is consistently shown to affect male reproductive function by multiple mechanisms, mostly elucidated in experimental models. The aim of the current single-center, observational, cross-sectional cohort study was to evaluate the prevalence of testis morphostructural alterations in a large cohort of men liv...

As a ubiquitously present metal, cadmium (Cd) represents a matter of great concern, especially considering its potential thyroid disrupting capacity. The study evaluated the connection between this environmentally relevant metal exposure and thyroid hormone levels. The DecodExpo study enrolled 425 participants (207 males and 218 females) with various disorders (236 participants) and healthy controls (189 participants). Collected blood samples were digested, and Cd levels were ...

Introduction: Iodine nutrition is critical for human health. In recent years the main focus was on the developing brain during pregnancy. In addition, iodine nutrition is essential for growth and development during adolescence. Iodine nutrition was recently low within the recommended range among adult Faroese living on local, iodine-rich marine food items. Dietary habits among young generations are drifting away from local foods, and this raises a concern that led us to perfor...