Endocrine Abstracts

Background: It is well established that life-long follow-up is required for patients with hereditary pheochromocytomas and paragangliomas (PPGLs), due to the potential of developing recurrent disease. However, whether follow-up of patients with sporadic PPGLs is necessary, remains unclear.Aims: To examine the prevalence and predictors of recurrent disease in patients with sporadic PPGLs.Materials and method: This multicenter study included retrospective ...

Prostate cancer (PCa) is one the leading causes of cancer-related deaths among men in developed countries. Therefore, identification of novel molecular and therapeutic approaches to tackle this pathology are urgently needed. In this scenario, our group has recently reported that elements of the cellular machinery controlling alternative splicing processes might be used as potential novel therapeutic tools against PCa and castration-resistant PCa (CRPC). In this context, RBM22 ...

Context: Mosaicism is a feature of several inherited tumor syndromes but is rarely systematically looked for in routine. MEN1 is an autosomal dominant hereditary syndrome characterized by several endocrine tumors affecting parathyroids, pancreas, and anterior pituitary most of the time, due to inactivating mutations in the MEN1 gene. Few cases of mosaicism in Multiple Endocrine Neoplasia type 1 (MEN1) have been described. MEN1 mosaicism is probably under-diag...

Introduction: A syndrome of MEN2A and Hirschsprung’s disease described in Israeli Jews of Moroccan descent is caused by Cys 618 Arg mutation, one of the less common causes of MEN2A. We aimed to define the clinical characteristics of a large cohort with this mutation from a multi-center Israeli registry.Methods: The Israeli MTC registry including 8 centers was searched retrospectively for results of RET mutational analysis. Patients with a Cys 618 Ar...

Human malignant pleural mesothelioma (MPM) is a rare but aggressive neoplasm, arising from pleural mesothelial cells, generally due exposure to asbestos. Of note, different growth factors and their receptors are involved in the pathogenesis of MPM and resistance to therapy. Chemotherapy with cisplatin (cis) and antifolates, like pemetrexed (PEM), is the first-line treatment for inoperable MPM. Growth hormone-releasing hormone (GHRH), besides stimulating GH secretion in the ant...

Glioblastoma (GBM; grade IV astrocytoma) is one of the most devastating endocrine-related cancer worldwide based on its locally aggressive behavior and because it cannot be cured by current therapies. Therefore, the identification of novel diagnostic and prognostic biomarkers, and especially efficient therapeutic targets is urgently needed. In this sense, defects in alternative splicing process are associated with poor survival and high aggressiveness in cancer, including GBM....