Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1

ea0081oc2.1 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

DLK1 expressing cells mark a population of progenitor cells in the adrenal cortex and contribute to the zonation of the adrenal gland

Mariniello Katia , Guasti Leonardo , Rognoni Emanuel

The adrenal cortex is a dynamic organ that undergoes self-renewal. In the mouse it is divided into two concentric layers, the outer zona glomerulosa (ZG) and the inner zona fasciculata (ZF), that secrete aldosterone and corticosterone, respectively. Capsular and subcapsular stem/progenitor cells differentiate and migrate in a centripetal fashion to repopulate the gland until they reach the juxtamedullary region where they undergo senescence and apoptosis. Cell fate mapping stu...

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ea0081oc2.2 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Loss of SUMO-specific protease 2 leads to adrenal insufficiency limited to glucocorticoids

Dufour Damien , Dumontet Typhanie , Sahut-Barnola Isabelle , Onzon Meline , Pussard Eric , Wilmouth Jr James , Olabe Julie , Levasseur Adrien , Bossis Guillaume , Yeh Edward , Val Pierre , Martinez Antoine , Anne-Marie Lefrancois-Martinez

The adrenal gland produces corticosteroids essential for hydromineral and metabolic homeostasis. It is organised, in mice, in two concentric layers. The zona glomerulosa (zG) and fasciculate (zF), renewed from progenitors located in the capsular periphery. Centripetal renewal and maintenance of cortical zonation are dependant of a balance between WNT/β-catenin and ACTH/PKA signalling pathways. They provide recruitment and consecutive differentiation of progenitors into zG...

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ea0081oc2.3 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Loss of lysine demethylase KDM1A in GIP-dependent bilateral macronodular adrenal hyperplasia with Cushing’s syndrome

Chasseloup Fanny , Bourdeau Isabelle , Tabarin Antoine , Regazzo Daniela , Dumontet Charles , Ladurelle Nataly , Tosca Lucie , Amazit Larbi , Proust Alexis , Scharfmann Raphael , Fiore Frederic , Tsagarakis Stylianos , Vassiliadi Dimitra , Maiter Dominique , Young Jacques , Lecoq Anne-Lise , Demeocq Vianney , Salenave Sylvie , Lefebvre Herve , Cloix Lucie , Emy Philippe , Desailloud Rachel , Vezzosi Delphine , Scaroni Carla , Barbot Mattia , de Herder Wouter , Pattou Francois , Tetreault Martine , Corbeil Gilles , Dupeux Margot , Lambert Benoit , Tachdjian Gerard , Guiochon-Mantel Anne , Beau Isabelle , Chanson Philippe , Viengchareun Say , Lacroix Andre , Bouligand Jerome , Kamenicky Peter

Context: Primary bilateral macronodular adrenal hyperplasia (PBMAH) with glucose-dependent insulinotropic polypeptide (GIP)-dependent Cushings syndrome is caused by ectopic expression of GIP receptor in the adrenal tissue. The bilateral nature of this adrenal disease suggests germline genetic predisposition. We aimed to identify the molecular driver event responsible for ectopic GIP receptor expression in PBMAH.Methods: We conducted an internationa...

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ea0081oc2.4 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Autonomous cortisol secretion in adrenal incidentalomas and risk of fragility fractures: a large cross-sectional study

Zavatta Guido , Vicennati Valentina , Altieri Paola , Colombin Giacomo , Coscia Kimberly , Fanelli Flaminia , Malagrino1 Matteo , Magagnoli Matteo , Tucci Lorenzo , Pagotto Uberto , Di Dalmazi Guido

Context: Autonomous cortisol secretion (ACS) has been associated with a higher prevalence of osteoporosis and fragility fractures in several studies. However, the data rely on heterogeneous studies and criteria for osteoporosis screening in this population are still debated.Objective: To assess the prevalence of fragility fractures and contributing factors in a large cohort of patients with adrenal incidentalomas.Methods: We review...

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ea0081oc2.5 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Elevated serum free cortisol is a strong predictor of mortality in hospitalized patients with Covid-19 irrespective of dexamethasone treatment

Rozenfeld Karina , Izkhakov Elena , Moshiashvili Miguel , Oster Howard , Tordjman Karen , Shefer Gabi , Greenman Yona

Serum total cortisol has been linked to increased mortality in patients with Covid-19, but its reliability in critically ill patients is limited. We examined the association between serum free cortisol (SFC) levels and clinical outcomes in patients hospitalized with Covid-19 between 5/5/2020 and 1/3/2021 in our institution. Methods: SFC was measured in blood samples collected at patients admission, prior to any medical treatment. Patients fil...

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ea0081oc2.6 | Oral Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Activity of abiraterone acetate in the management of cushing syndrome associated to advanced adrenocortical carcinoma: results of the ABACUS trial

Puglisi Soraya , Cosentini Deborah , Grisanti Salvatore , Basile Vittoria , Lagana Marta , Ferarri VittorioDomenico , Abate Andrea , Calabrese Anna , Rossini Elisa , Perotti Paola , Saba Laura , Pia Anna , Sigala Sandra , Berruti Alfredo , Terzolo Massimo

Background: More than 50% of adrenocortical carcinomas (ACC) in adults are associated with cortisol excess that makes tumor management challenging and has a negative impact on patient outcome. Abiraterone acetate (AA) is an irreversible inhibitor of the 17α-hydroxylase/C17, 20-lyase (CYP17 enzyme) that is used in patients with prostate cancer, in whom it leads to suppression of cortisol and androgens. The aim of this study was to assess the activity of AA to control corti...

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Endocrine Abstracts

European Congress of Endocrinology 2022