ECE2022 Eposter Presentations Thyroid (219 abstracts)
Male gender is independent factor of poor prognosis in medullary thyroid cancer
Arseny Semenov 1,2 , Roman Chernikov 1 , Dmitry Buzanakov 1 , 2 , Anna Zolotukho 2 , Anna Uspenskaya 1 , Nataliya Gorskaya 1 , Ivan Ziborov 2 , Igor Chinchuk 1 , Konstantin Novokshonov 1 , Yuliya Karelina 1 , Fedorov Elisey 1 , Viktor Makarin 1 , Dina Rebrova 1 , Shamil Shihmagomedov 1 & Iliya Sleptsov 1,2
1Saint Petersburg State University, Saint Petersburg State University clinic, Saint-Petersburg, Russian Federation; 2Saint Petersburg State University, Medical Faculty, Saint-Petersburg, Russian Federation
Background: The medullary thyroid carcinomas comprise 5-7% of all thyroid carcinomas. At the same time, they are responsible for up to 13% of all deaths of thyroid cancer.Incidence of sporadic medullary thyroid cancer in population 5-6 time higher in women, probably partially because women are likely to have thyroid nodules and undergo medical examination.
Objective: The aim of the study is to determine how gender affects prognosis in patients with medullary thyroid carcinoma
Materials and methods: A continuous retrospective cohort study of patients who underwent primary surgery for medullary thyroid carcinoma in 2010-2020 at the N.I. Pirogov Clinic for Advanced Medical Technologies, Saint Petersburg University, was conducted. Preoperative ultrasound data, basal serum calcitonin levels preoperatively and postoperatively on the 1st day after surgery, as well as histological examination data of surgical specimens were evaluated. Postoperative observation data for a period of at least 1 year were obtained for 347 patients. Patients were distributed by age to 6 age groups. Data analysis was performed using Tibco Statistica 14
Results: Patients were divided by percentage or by age and compared with each other. Male patients had a larger tumor size and basal calcitonin levels in all groups except over 70 years of age. The difference was significant and did not depend on the RET status of heritability. It is noted that with increasing age, the odds ratio of an aggressive course increased from 3.2 in all patients under 50 years to 9.25 from 50 to 60 years and 49.9 from 60 to 70 years. In the group over 70 years of age, OR is not significant due to the small number of patients and the death of most male patients with aggressive forms at an earlier age. Mostly medullary thyroid cancer even metastatic is indolent and found occasionally so difference caused by higher rate of symptomatic disease in men was found insignificant. The male sex significantly correlated with the risk of invasion into the surrounding tissues 0.715503, necrosis 0.547170, perineural growth 0.550827, the number of affected lymph nodes in the central and lateral tissues of the neck 0.465853 and 0.406780 respectively, with a probability of repeated interventions 0.485560 and a shorter recurrence period 0.444950. With a weak correlation with the node size of 0.255830.
Conclusion: the male gender is associated with a greater risk of aggressive course of medullary thyroid carcinoma, less effective surgical treatment, and greater need for target therapy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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