Endocrine Abstracts

Introduction: The association of multi-organ autoimmune disorders is described. We report a case of Hashimoto’s thyroiditis (HT) and primary biliary cholangitis (PBC), both are a chronic autoimmune inflammation, with lymphocytic infiltration and destruction of thyroid cells for (HT) and progressive destruction of intrahepatic bile ducts leading to cirrhosis for (PBC)

Case report: 54-year-old female patient, followed for (PBC) at cirrhosis stage admitted for evacuation of refractory ascites. Interrogatory: signs of hypothyroidism: asthenia, constipation, chilliness and hair loss, Physical examination of the patient revealed bradycardia at 55bpm, palpable thyroid, end signs of hepatocellular insufficiency: subicterus and stellate angioma. Blood tests revealed a hypothyroidism (TSH: 26.6μUI/ml; T4: 5.2 pmol/l), end anti-Thyroperoxidase and anti-mitochondria type 2 antibodies are positive.

Discussion: PBC is frequently associated with other autoimmune diseases, the most common of which are Hashimoto’s thyroiditis, Gougerot Sjögren’s disease, celiac disease, and scleroderma, their screening must be systematic in order to initiate early and adequate treatment. As soon as an autoimmune disease is diagnosed, the search for other organ damage is necessary in order to initiate treatment in the early stages, which improves the patient’s overall prognosis.