ECE2022 Eposter Presentations Thyroid (219 abstracts)
Graves’ disease: Particularities in the pediatric population
Dhoha Ben Salah , Kawthar El ARBI , Asma Zargni , Mouna Elleuch , Cyrine Chehaider , Mnif Fatma , Nadia Charfi , Mouna Mnif , Nabila Rekik Majdoub , Faten Haj Kacem Akid & Mohamed Abid
Hedi Chaker Hospital, Department of Endocrinology, Sfax, Tunisia
Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism in pediatric patients, up to 95% in some studies.
Observation: We report the observation of a 6-year-old female who consulted for a behavioral disorder made of agitation and lack of concentration. She had a family history of autoimmune thyroid disease. On examination, an accelerated statural growth rate of +2DS was noted. She had a significant palpebral retraction without exophthalmia. A biological check-up showed a blocked TSH level at 0.01µU/ml associated with a high T4 at 26.4 pmol/l. In addition, TSH receptor antibodies blokers (trab) were positive at 17.8 U/l for a normal value (NV) of less than 1.5. Anti-thyroperoxidase antibodies were positive at 148 U/l (NV<20U/l). The thyroid ultrasound was normal with a normal volume and homogeneous gland. The diagnosis of Graves’ disease was retained and a treatment with methimazole was started at a dose of 0.5 mg/kg/d. The thyroid check-up 3 months later was normal. The treatment is in progress.
Conclusion: GD is a rare condition in children and affects mostly older children with a clear female predominance. Although rare, GD remains the most frequent cause of hyperthyroidism in children. Diagnosis is easier if exophthalmia is present, which is a very specific sign of this condition. However, palpebral disorder is the most common as exophthalmia is less frequent in children. Medical treatment is based on synthetic antithyroid drugs.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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