Endocrine Abstracts

Background: In recent years, thyroid diseases have been occupying the top places in the structure of the endocrine pathology. There exists tight functional relationship between the thyroid and reproductive systems, which leads to a high probability of the development of combined disorders in one of these links of homeostasis. Vitamin D deficiency in the population remains a global problem. The purpose of the study is to investigate the effect of myoinositol on the thyroid status of women with subclinical hypothyroidism on the background of autoimmune thyroiditis and vitamin D deficiency.

Materials and methods: The study included 102 patients, aged 18-42 years, with subclinical hypothyroidism on the background of autoimmune thyroiditis. The patients were randomly subdivided into two groups. Patients of the first group (n= 52) before the main treatment by levothyroxine at a dose 37,5±12,5, received the myoinositol supplementation at a dose of 2000 mg/day, and cholecalciferol at a dose of 2000 IU/day. Patients of the second group (n= 50) before the main treatment received only cholecalciferol at a dose of 2000 IU/day.

Results: Vitamin D deficiency was observed in 91.68 % of women with subclinical hypothyroidism, and vitamin D insufficienty was observed in 8.32 %. A negative correlation was found between the level of 25 (OH) D and the level of ATPO (r=-0.194, P<0, 05). The myoinositol supplementation together with vitamin D led to a probable increase in the content of 25 (OH) D in the serum, as well as to a decrease in the titer of ATPO.

Conclusions: The positive effect of myoinositol drugs together with vitamin D on the functional state of the thyroid gland, on the level of antibodies to TPO in women of reproductive age with subclinical hypothyroidism on the background of autoimmune thyroiditis and vitamin D deficiency has been established.