ECE2022 Eposter Presentations Thyroid (219 abstracts)
Dyshormonogenic goiter: about three cases
Marwa Ben Njima 1 , El Omri Malika 1 , jihen haouas 2 , Meherzi Abir 2 , Ghammmam Monia 2 , Mouna Bellakhdhar 2 , nihed abdessayed 2 , Kermani Wassim 2 & Abdelkefi Mohamed 2
1Sousse, ENT, Sousse, Tunisia; 2Hôpital Universitaire Farhat Hached Sousse, ENT, Sousse, Tunisia
Introduction: Dyshormonogenetic goiter (DG) is considered as a form of thyroid hyperplasia due to enzymatic defects in hormone synthesis. The architectural polymorphism and cellular atypia may mimic thyroid neoplasms and cause difficulties in differential diagnosis.
Results: We report 3 cases of DG occurring in one females and two males who were aged 20, 9, and 7 years old, respictively. All patients presented with clinically evidence of goiter. Hypothyroidism was documented before the histological diagnosis was made in all patients. The thyroid gland was enlarged and multinodular in all cases. Cervical ultrasound and thyroid scintigraphy were performed for all patients. The ultrasound showed a multinodular goiter in all patients. The scintigraphy showed a global hyperfixation of the thyroid for two patients with a right hypofixing zone for one patient. All patients underwent surgical treatment. A total thyroidectomy for two patients and a right loboishmectomy for one patient. The anatomopathological examination confirmed a DG in all cases. The evolution was favorable for all patients and without recurrence.
Conclusion: DG is a rare entity, representing one of the causes of congenital hypothyroidism. It is morphologically characterized by architectural and cellular pleomorphism that may mimic thyroid malignancy and cause difficulties in differential diagnosis that explains the delema of establishing surgical indications.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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