ECE2022 Eposter Presentations Thyroid (219 abstracts)
Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report
Martina Tomasovic 1 , Marija Sinik 1 , Bojan Joksimovic 1 , Milena Lackovic 1 , Vladimir Samardzic 1 , Marina Vujovic 1 , Zoran Gluvic 1 , Milan Obradovic 2 , Sonja Zafirovic 2 & Esma R. Isenovic 2
1Zemun University Clinical Hospital, Department of Endocrinology and Diabetes, Belgrade, Serbia; 2“VIN&Cbreve;A” Institute of Nuclear Sciences – National Institute of thе Republic of Serbia, Department of Radiobiology and Molecular Genetics, Belgrade, Serbia
Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became vesicular shortly after and then scaly. After two weeks, skin changes were entirely restored with no scaring. Taking into account thorough epidemiological survey, clinical course, and performed diagnostics, presented skin changes were diagnosed as Hand, Foot, and Mouth disease (HFMD). Clinicians must be aware of the side effects of used drugs, especially after their introduction. Some clinical presentations could only resemble expected or well-known side-effects, intolerance, or hypersensitivity to the used drug. Every clinical presentation associated with any drug introduction must be thoroughly evaluated. The presented case revealed that skin changes of HFMD mimicked PTU-induced vasculitis. Keywords: Propylthiouracil, autoimmunity, Hand, Foot and Mouth Disease
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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