Endocrine Abstracts

Background: Autoimmune inflammatory syndrome induced by adjuvants (ASIA syndrome), include the different conditions linked following exposure to an adjuvant. Auto-immune thyroiditis following vaccination as an auto-immune/inflammatory syndrome is rarely reported. In the era of mass vaccination against SARSCov2, there is limited information about cases of auto-immune thyroid disease as an ASIA syndrome following SARS-CoV-2 vaccination.

Case: A 19years old man, with no medical history was presented five days after second vaccination doses against SARS-CoV-2 with unusual clinical symptoms of hypothyroidism as acute rhabdomyolysis with a pericardial effusion, and a very high level of thyroid stimulating hormone, decreased free thyroxin and higher level of peroxidase and thyroglobulin thyroid autoantibody. One week after L-thyroxin treatment CK was normal and kidney function is normalized with a remarkable improvement of thyroid functions.

Conclusion: Rhabdomyolysis and pericardial effusion can occur as severe symptoms of Hashimoto thyroiditis as an ASIA syndrome after vaccination against SARS-CoV-2. Key words:ASIA syndrome - SARS-CoV-2 vaccine - Hashimoto’s thyroiditis - Acute rhabdomyolysis - pericardial effusion.