Endocrine Abstracts

Aim of the study: to assess the interaction between TSH and the most common geriatric syndromes in the cohort of centenarians

Materials and Methods: It was a longitudinal study, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and МOCA scores. We analyzed the interactions between TSH, metabolic parameters, functional status and cognitive functions in centenarians. In one year after the investigations we contacted patients’ relatives or social workers to find out about patients’ status. The statistical analysis was performed using IBM SPSS Statistics Version 26. Statistically significant were differences with р< 0,05.

Results: Mean age of the patients was 98,3 (±1,9) years, while 87,8% of the cohort were women. Analyzing functional status we found out that 34,4% of the patients were frail, and the number of prefrail patients was 56,2%. Cognitive impairments of different severity were presented in 84,4% of the patients. In 59% of the patients HbA1c was below 6%, 33% had concentrations between 6 and 6,4% and only in 8% we found HbA1c higher than 6,5%. The median level of TSH was 2,26 mIU/l [1,8;3,6] with a tendency to higher normal concentrations. TSH was negatively correlated with C-reactive protein (r= -0,4, P<0.05) and positively correlated with albumin levels (r= 0,26 P=0,038). The interaction between the TSH and chronic pain severity measured by VAS was negative (r= -0,03, P=0,021). Cognitive status of centenarians assessed by MMSE showed a positive correlation with TSH levels (r= 0,38, P=0,011).

Conclusion: In the cohort of centenarians higher levels of TSH seem to play a protective role in maintaining cognitive functions and nutritional status; lower TSH levels seem to be linked with the higher intensity of chronic pain.