Endocrine Abstracts

Introduction: Polycystic ovary syndrome is a real public health problem and is the most frequent cause of hyperandrogenism in women of childbearing age. The therapeutic management of PCOS depends on the patient’s phenotype and associated comorbidities. The aim of our work is to study diagnosis and evolution after treatment of PCOS in our population.

Material and method: This is a retrospective descriptive study of 78 patients followed for PCOS at the Endocrinology Diabetology and Nutrition Department of the Mohammed VI University Hospital of Oujda in the eastern region of Morocco. The diagnosis of PCOS is based on the criteria of the Rotterdam Consensus of 2003. All patients underwent an interrogation, clinical examination, biological assessment and pelvic ultrasound. The collected data were analyzed by SPSS version 21 software.

Results: The average age of patients was 24 years. Hirsutism was the most frequent reason for consultation in 97.2% of cases with severe hirsutism in 12% of cases, followed by cycle disorders (84.3%), and acne in 55.7%. The average BMI was 26.1 ± 5.8 kg/ m² obesity was observed in 20% of patients, with abdominal obesity in half of the cases. Therapeutically, all our patients were put on dietary hygienic measures and metformin, the estrogen-progestogen contraceptive was indicated in 38% of patients and spironolactone in 26%, with a combination of these 2 treatments in 18% of cases. The evolution after at least 6 months of treatment revealed a very satisfactory improvement of the clinical signs with a decrease in the frequency of hair removal and a reduction in the density and darkness of the hairs.

Discussion-Conclusion: PCOS is a real problem in young women, which has psychological and social repercussions as well as metabolic ones. Its treatment should aim to: reduce hyperandrogenism, improve metabolic status and quality of life, and restore fertility. Our results are consistent with those reported in the literature.