Endocrine Abstracts

Objectives: To determine the histopathological changes of the endometrium that occur during the period of perimenopause and postmenopause and to determine their association with the presence of obesity, diabetes, thyroid disorders and the levels of FSH, LH, estradiol, insulin and parathormone.

Material and methods: This study involved 120 patients with fractionated explorative curettage due to abnormal uterine bleeding. The control group consisted of 40 healthy women without fractionated explorative curettage. Anamnestic data were taken from from all respondents. Body height and weight were measured. This laboratory analyses were performed: Glycemia, HbA1c, Hormonal Status (FSH, LH, Estradiol, Insulin, TSH, Thyroxine and Parathormone).

Results: The most common pathological change of the endometrium was an endometrial polyp. Patients with explorative curettage were older than healthy women and had significantly higher Body Mass Index, higher levels of serum glycemia, triglycerides, serum insulin, FSH, LH, PTH and lower estradiol levels. Patients in the experimental and control group did not differ significantly in TSH and thyroxine levels.

Conclusions: In the period of perimenopause and postmenopause, there are changes in the genital organs, but also there are endocrine disorders. According to our study, some of them are related to the occurrence of changes in the endometrium and the need for fractional explorative curettage as a diagnostic procedure.