Endocrine Abstracts

Background and Objectives: Polycystic ovary syndrome (PCOS) is a common endocrine disorder with heterogeneous eatiology. It is characterized by irregular menses and or oligo/anovulation, hyper-androgenism, and polycystic ovaries. The prevalence and diagnosis of PCOS changes depending on which clinical criteria are utilized to confirm the diagnosis. The prevalence can be high as 15%–20% when the Rotterdam criteria are used. However, there is significant inter-individual variation in presentation. We have studied the socio-demographic and clinical characteristics of PCOS patients attending the Endocrinology clinic in a tertiary care institute in Sri Lanka.

Methods: A descriptive cross sectional study was conducted from September 2019 to September 2020 at the Endocrinology Unit of the National Hospital of Sri Lanka. Systematic sampling was done recruiting PCOS patients diagnosed with Rotterdam criteria. After obtaining informed written consent, the data was collected using an interviewer administered questionnaire. HOMA-IR was calculated using the fasting insulin and blood glucose level.

Results: The study enrolled sixty females. The mean age was 26.7 years (range 18-44). The mean weight was 64.8 (SD=11.9) kg and BMI was 27.1 (SD=4.8) kg/m^-2. According to Asian BMI cut-offs, 1 (1.7%) patient was underweight and 13 (21.7%) had normal weight. Forty six (76.7%) had their weight in the overweight or obese category. Fifty four (90.0%) patients had clinical or biochemical evidence of hyperandrogenism while 24 (40.0%) females had polycystic ovaries on trans-abdominal ultrasound scan and 50 (83.3%) partipants had irregular menstrual cycles. According to the body fat percentage assessed by the whole body DEXA scan 4.1% of the study population had normal body fat, while 50.0% and 45.8% had overweight and obesity respectively. HOMA-IR detected 61.1% patients to have high insulin resistance. Out of the patients who had USS of the abdomen 27.5% had co-existent non-alcoholic fatty liver. Fifty four percent of the patients had sub/infertility.

Conclusions: The majority of the population were overweight or obese and had higher prevalence of insulin resistance and non-alcoholic fatty liver. Out of the clinical characteristics used to make the diagnosis of PCOS, the presence of clinical or biochemical evidence of hyperandrogenism and irregular menstrual cycles are more common than the detection of polycystic ovaries on trans-abdominal USS. The higher prevalence of overweight, obesity, insulin resistance and NAFLD associated with PCOS makes the diagnosis and management of the disease crucial to prevent long term consequences of the disease