ECE2022 Eposter Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Assessment of a new marker of polycystic ovary syndrome in morbidly obese women
Ibtissem Oueslati 1 , Amani Terzi 1 , Bassem Hammami 2 , Hana Belhadj Hassen 1 , Seif Boukriba 3 , Habiba Mizouni 3 , Moncef Feki 2 & Melika Chihaoui 1
1La Rabta University Hospital, Department of Endocrinology, Tunis, Tunisia; 2La Rabta University Hospital, Laboratory of Biochemistry, Tunis, Tunisia; 3La Rabta University Hospital, Department of Radiology, Tunis, Tunisia
Introduction: Polycystic ovary syndrome is the most common cause of anovulatory infertility in women. Anti-Mullerian Hormone (AMH) was considered a reliable marker for the diagnosis of polycystic ovary syndrome (PCOS). However, AMH level is influenced by age and body mass index. The aim of this study was to analyze the performance of the (LH x AMH)/FSH ratio in the diagnosis of PCOS in women with morbid obesity.
Methods: This was a cross-sectional study including 50 women of reproductive age with morbid obesity (body mass index ≥ 40 kg/m2). Each patient underwent a clinical examination, biological and hormonal assays, and an ovarian ultrasound between the third and fifth day of the menstrual cycle. PCOS was diagnosed according to the Rotterdam criteria. (LH x AMH)/FSH ratio was calculated.
Results: Participants had an average age of 34.2 ± 7.5 years. PCOS was diagnosed in 20 women (40%). The (LH x AMH)/FSH ratio was positively correlated with Ferriman and Gallwey score (r=0.602, P=0.002), testosterone level (r=0.586, P<10-3), delta 4-androstenedione level (r=0.343, P=0.01), and ovarian volume (r=0.442, P=0.004). However, this ratio was not correlated with age, body weight, body mass index, and waist circumference. Its mean value was 3.34 in women with PCOS and 0.84 in those without PCOS (P< 10-3). The area under the ROC curve for the diagnosis of PCOS was 0.807 for the (LH x AMH)/FSH ratio, 0.714 for the AMH level, and 0.788 for the LH/FSH ratio. A (LH x AMH)/FSH ratio ≥ 1 was positively associated with PCOS (Odds ratio= 10.2, P=0.001, 95%-CI: 2.39-43.5) with a sensibility of 85%.
Conclusion: Our results showed a significant association between (LH x AMH)/FSH ratio and PCOS. This new ratio was not influenced by age and obesity. Therefore, it may be a good screening tool for PCOS in women with morbid obesity.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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