ECE2022 Eposter Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Cardiopulmonary capacity and muscle strength in transgender women in long-term gender-affirming hormone therapy: a cross-sectional study
Leonardo Alvares 1,2 , Marcelo Rodrigues dos Santos 3 , Francis Ribeiro de Souza 3 , Lívia Marcela Santos 1 , Elaine Maria Frade Costa 2 , Berenice Bilharinho de Mendonça 2 , Maria Janieire de Nazaré Nunes Alves 3 & Sorahia Domenice 2
1Centro Universitário São Camilo, Brazil; 2Faculdade de Medicina da Universidade de São Paulo, Unidade de Endocrinologia do Desenvolvimento, São Paulo, Brazil; 3InCor - Instituto do Coração do Hospital das Clínicas da FMUSP, São Paulo, Brazil
Introduction: Effects of prior exposure to testosterone (T) during puberty on the performance of transgender women (TW) in estrogen therapy undergoing physical effort are not known, mainly about cardiopulmonary capacity (CPC). Objectives: To evaluate CPC and muscle strength in TW undergoing long-term gender-affirming hormone therapy (GAHT). Methods: A cross-sectional study was carried out with 15 TW (34.2±5.2 yo), 13 cisgender men (CM) and 14 cisgender women (CW). TW were in hormone therapy for 14.4 ±3.5 years. Bioimpedanciometry, handgrip test and CP exercise on a treadmill with an incremental effort were done. Results: The medium strength (kg) was 35.3±5.4 in TW, 29.7±3.6 in CW, and 48.4±6.7 in CM (TWvsCW P=0.0250;TWxCM P<0.0001). About Median Strength/FFM (Free Fat Mass), a mean of 0.6 was observed in TW group and 0.7 in both others (TWvsCW P=0.1432; TWvsCM P=0.0301). Mean VO2peak (L/min) of TW was 2606±416.9, of CW 2167±408.8 and of CM 3358±436.3 (TWvsCW P=0.0238; TWvsCM <0.0001; CWvsCM P<0.0001). Analysis of VO2 max/FFM (L/min/kg), TW´s rate was 47.7±5.1, CW´s was 53.3±8.3 and CM´s was 52.4±5.8 (TWvsCW P=0.0704;TWvsCM P=0.1357). O2pulse of TW was intermediate between CW and CM (TWvsCW P=0.0131, TWvsCM P<0.0001). There was high correlation of VO2peak and FFM/height2 (FFM/Hgt2) of TW (r=0.7388;P=0.0017) not seen in the other groups. Percentage predicted Heart Rate at effort was higher in TW (103.1) than in CW (96.5) (P=0.0065) and CM (99.2) (P=0.1373). Discussion: By integrating the data set we may conjecture that TW undergoing long-term GAHT could have an exacerbated ergoreflex and a decreased functionality of the muscular unit. Conclusion: Cardiopulmonary capacity, mainly peak VO2, is blunted in TW after long-term hormone therapy. However, TW still present slightly higher exercise performance when compared with CW.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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