ECE2022 Eposter Presentations Reproductive and Developmental Endocrinology (93 abstracts)
Associations of serum AMH levels and hormonal, metabolic and cardiovascular parameters in adult men
Veronika Tandl 1 , Caterina Colantonio 2 , Christoph W Haudum 1 , Barbara Hutz 1 , Ewald Kolesnik 2 , Albrecht Schmidt 2 , Andreas Zirlik 2 , Nicolas Verheyen 2 , Thomas R Pieber 1 & Barbara Obermayer-Pietsch 1
1Medical University of Graz, Division of Endocrinology and Diabetology, Graz, Austria; 2Medical University of Graz, Division of Cardiology, Graz, Austria
Background: Anti-Müllerian hormone (AMH) is well known for its association with ovarian follicular count and ovarian reserve in general as well as for its recruitment of primordial follicles in women. With an explicit decrease in menopause, it is mainly used for clinical questions from in-vitro-fertilisation to polycystic ovary syndrome. Interestingly, AMH levels in men are quite high during lifetime, but there is only few data about its relevance and potential effects in adult men. The aim of our study was to investigate and describe AMH levels in men in association with a number of hormonal, metabolic and cardiovascular parameters and whether there are links to physiological or pathophysiological functions.
Methods: We analysed data from the BioPersMed cohort (Bio markers for Personalized Medicine), a prospective cohort of asymptomatic subjects at cardiovascular risk. Clinical parameters, past medical history, AMH, hormonal profiles including androgens, fasting glucose and insulin values as well as oral glucose tolerance tests, lipid measurements including high- (HDL) and low-density (LDL) lipoproteins, inflammation markers such as C-reactive protein (CRP) and others were analysed as well as anthropometric parameters, DXA(dual energy X-ray absorptiometry)-derived body composition.
Results: Out of n = 1022 healthy volunteers, we identified 389 men (38% of the cohort) with a mean age 58 +/- 9 years. While AMH was BMI-dependent (P=0.0113), and decreased slightly with age (P=0.03), it was inversely associated with pituitary hormones LH (luteotropic hormone, P=4.5e-5) and FSH (follicle stimulating hormone, P=1.6e-10). The highest AMH quartiles showed an inverse association with C-peptide, but also HDL, while androgens or SHBG were not significantly different between groups, in contrast to pronounced differences of these parameters according to BMI categories.
Conclusion: AMH in men is an interesting, however neglected biomarker with a number of potential associations with hormonal, but also metabolic and potentially cardiovascular risk profiles. Its clinical value has to be determined in follow-up studies, but AMH in men might become an important health marker and needs further investigation.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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