Endocrine Abstracts

Objective was to study features of clinical semiology, their value for differential diagnostics in population of patients with the sporadic and family IAH anamnesis.

Materials and methods.: 71 IAH patients with intracellar adenoma of a hypophysis. Patients with IAH were divided into two alternative groups: the 1st group - 50 (70,4 %) patients with environmental factors without the burdened family anamnesis and 2nd - 21 (29,6 %) with the burdened family anamnesis, including with a panmiksiya - 9 (2,7 %) and an inbriding - 12 (16,9 %) patients. Average patients age was 18-70 years (44,5±3,85 years). At the same time the greatest number of the arrived IAH patients to fall on age from 35 (23,9 %) to 40 (25,4 %) years and to a lesser extent be elderly to 30 (18,3 %) and 55 (5,6 %) and is more than years that will be coordinated with literary data. It should be noted that at patients of 2-group with hereditary IAH signs is more often than patients of 1-group - without hereditary signs prevail frequency of clinical signs, such as sexual violations - 26,5 %, decrease in sight - for 40,2 %, headaches - for 26,5 %, doubling in eyes - for 15,0 %, visual discomfort - for 12,5 %, olfactory violations - for 19,8 %, vegetative crises - for 12,3 %, duration of a disease among women 5-20 years - for 12,3 and 24,6 %, but to a lesser extent till 20 and more than 21 years - for 23,2 and 15,2 %, and among men of such difference it is not revealed. Frequency of complaints in 1-group on visual violations it is revealed, decrease in visual acuity at IAH patients with a tumor to 10 mm at 10 % surveyed, to 20 mm - 70,0 %, with huge - 100 %, at patients of 2-groups - 50,0 %, 87,5 % and 72,7 %. At patients with the family it is IAH the main clinical symptoms of a disease associate: - visual, sexual, headaches, vegetative crises, climax come aged till 20-25 years, and time of establishment of the diagnosis - 10-20 years; - adenomas> 10 мм which progress quicker, in huge adenomas, with the heavy course of a disease more often come to light, than at patients from the single is IAH; - the IAH family form and development of clinical symptoms at early age should be object of diagnostic screening.