Endocrine Abstracts

Aim: – to study the functional status of pituitary-gonades-cortex (PGC) axis in women with Cushing syndrome (CS)

Materials and methods: Weevaluated 25 women with ACTH-depended CS without other associated pathology. Mean age of patients was 28,3 years-old\. All patients have complaints to amenorrhea and primary infertility. Control group constituted by 20 healthy women with same age All patients underwent clinical and biochemical evaluations including endocrine check, lipids profile, hormonal profile in 14 day of menstrual cycle (LH, FSH, prolactin, free testosterone, estradiol, progesterone, etc), genitalia ultrasonography, electroencephalography (EEG), height, weight, BMI, waist circumference (WC), hip circumference (HC), waist-hip ratio, questioning and other studies.

Results: The investigation ofhormonal profileshowed anovulation in 19 patients (76%) (mean LH ranged 3,7±1, 2 mIU/l, FSH 4,4±1,5 mIU/l) in 14 day of the menstrual cycle and high range of free testosterone levels (mean 3,6±0,3 ng/ml). Besides that, all patients have hypercortisolemia. (P<0,05). The investigation of levels of estradiol and progesterone in 7,14, 21 days of menstrual cycle showed of their partial decrease. Most of the patients had central obesity with BMI > 35 kg/m². WC was in normal range 104,3 ± 7, 4 cm, HC = 85, 6 ± 5,3 cm, whereas waist-hip ratio > 1, 22. Blood tests showed dyslipidemia in all patients (100%).

Conclusions: Mostfertilewomen with ACTH-DCS (76%) have anovulation with high range of free testosterone in all patients with partial decrease of estradiolum, progesterone (secondary hypogonadism).