Endocrine Abstracts

The purpose of the study: is to study the frequency of postoperative hypopituitarism after transnasal hypophysectomy (THE) in patients with pituitary adenomas.

Material and methods: Under our observation there were 24 patients with NFPA, of whom women were 14, men - 10. The average age of patients was 36.4 years. Total of 24 patients were performed for the period from 2016 to 2021 33 surgery in the neurosurgery department., of which THE - 32, 1 - bifrontal craniotomy. At the same time, 3 patients were 2 THE, in 3 - 3 THE, 4 patients with TGE also received radiation therapy. The whole patients were performed by research complex, which included radioimmune hormonal (STH, IGF-1, Prolactin, LH, FSH, TSG, ACTH, Cortizol, etc.), ophthalmological (Eye bottom, field of view) and X-ray studies (CT, MRI of the Turkish saddle).

Results: According to our data, postoperative panhibitionituitarism (deficiency of STH, LH, FSH, ACTH + Diabetes insipidus) developed in 6 patients (25%), postoperative partial hypopituitarism (deficiency of STH, LH, FSH) developed in 11 (45.8%) and 7 - STH deficiency (29.1%) developed. Thus, the most pronounced neuroendocrine disorders after THE were detected in 6 (25%) patients.

Conclusions: 1) In patients with adenomas of pituitary gland subjected to THE, it is recommended to monitor the levels of all tropic and peripheral hormones of pituitary glands both in the early and later postoperative periods. 2) patients with pituitary adenomas after THE need substitution hormone therapy with appropriate drugs depending on the level of hormones (desmopressin, sex and thyroid hormones, corticosteroid preparations, growth hormone).